Results 71 to 80 of about 1,018,982 (351)

Planetesimals in Debris Disks [PDF]

, 2017
Planetesimals form in gas-rich protoplanetary disks around young stars. However, protoplanetary disks fade in about 10 Myr. The planetesimals (and also many of the planets) left behind are too dim to study directly. Fortunately, collisions between planetesimals produce dusty debris disks.
George H. Rieke, Andrew N. Youdin
openaire   +3 more sources

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Modeling debris-covered glaciers: response to steady debris deposition [PDF]

The Cryosphere, 2016
Abstract. Debris-covered glaciers are common in rapidly eroding alpine landscapes. When thicker than a few centimeters, surface debris suppresses melt rates. If continuous debris cover is present, ablation rates can be significantly reduced leading to increases in glacier length.
Leif S. Anderson, Robert S. Anderson
openaire   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Underestimated activity-based microplastic intake under scenario-specific exposures

Environmental Science and Ecotechnology
Despite increasing alarms over the health impacts of microplastics (MPs) due to their detection in human organs and feces, precise exposure evaluations remain scarce.
Kai Liu, Qingqing Li, Anthony L. Andrady, Xiaohui Wang, Yinan He, Daoji Li   +5 more
doaj   +1 more source

Remnants of the city

Materia Arquitectura, 2017
Contrary to what has historically happened with earthquakes that have repeatedly destroyed several cities in Chile, the 2010 earthquake was followed by an unprecedented and fruitful reflection that, from various disciplines, has tried to understand ...
Alejandro Crispiani, Tomás Errázuriz Infante   +1 more
doaj   +1 more source

A Spitzer IRS Study of Debris Disks Around Planet-Host Stars

, 2010
Since giant planets scatter planetesimals within a few tidal radii of their orbits, the locations of existing planetesimal belts indicate regions where giant planet formation failed in bygone protostellar disks.
Beichman, Beichman, Beichman, Bertone, Bessell, Bryden, Bryden, Bryden, Butler, C. A. Beichman, Carpenter, Chen, Chen, Cochran, Cutri, Dodson-Robinson, Fischer, Fischer, Geoffrey Bryden, Goldreich, Hauschildt, Hillenbrand, Høg, Ida, John M. Carpenter, Johnson, Johnson, Kurucz, Kóspál, Lawler, Moro-Martín, Peletier, Perryman, Quillen, Sarah E. Dodson-Robinson, Sato, Su, Tanner, Trilling, Valenti, Wright, Wright   +41 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source