Results 71 to 80 of about 1,045,539 (348)

Impact of planet--planet scattering on the formation and survival of debris disks

, 2014
Planet--planet scattering is a major dynamical mechanism able to significantly alter the architecture of a planetary system. In addition to that, it may also affect the formation and retention of a debris disk by the system.
Marzari, F.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Underestimated activity-based microplastic intake under scenario-specific exposures

Environmental Science and Ecotechnology
Despite increasing alarms over the health impacts of microplastics (MPs) due to their detection in human organs and feces, precise exposure evaluations remain scarce.
Kai Liu, Qingqing Li, Anthony L. Andrady, Xiaohui Wang, Yinan He, Daoji Li   +5 more
doaj   +1 more source

Numerical simulation of debris flows triggered from the Strug rock fall source area, W Slovenia [PDF]

, 2006
The Strug landslide was triggered in December 2001 as a rockslide, followed by a rock fall. In 2002, about 20 debris flows were registered in the Kosec village; they were initiated in the Strug rock fall source area.
Fazarinc, Rok, Hojnik, Tomaž, Krzyk, Mario, Majes, Bojan, Mikoš, Matjaž, Rajar, Rudolf, Četina, Matjaž, Žagar, Dušan   +7 more
core   +1 more source

Silica-Rich Bright Debris Disk around HD 15407A

, 2012
We report an intriguing debris disk towards the F3V star HD 15407A, in which an extremely large amount of warm fine dust (~ 10^(-7) M_Earth) is detected. The dust temperature is derived as ~ 500-600 K and the location of the debris dust is estimated as 0.
Bohren, Dorschner, Fabian, Fujiwara, Hammel, Holman, Houck, Ishiguro, Kemper, Kenyon, Koike, Lisse, Melis, Mikouchi, Murakami, Onaka, Oudmaijer, Rhee, Sargent, Takeda, van Leeuwen, Wyatt   +21 more
core   +1 more source

Spitzer IRS Spectroscopy of the 10 Myr-old EF Cha Debris Disk: Evidence for Phyllosilicate-Rich Dust in the Terrestrial Zone [PDF]

, 2011
We describe Spitzer IRS spectroscopic observations of the 10 Myr-old star, EF Cha. Compositional modeling of the spectra from 5 {\mu}m to 35 {\mu}m confirms that it is surrounded by a luminous debris disk with LD/L\star ~ 10-3, containing dust with ...
Currie, Thayne, Lisse, Carey M., Rieke, George H., Sicilia-Aguilar, Aurora, Su, Kate   +4 more
core   +4 more sources

Post-main-sequence debris from rotation-induced YORP break-up of small bodies II : multiple fissions, internal strengths and binary production [PDF]

, 2020
Over one quarter of white dwarfs contain observable metallic debris from the breakup of exo-asteroids. Understanding the physical and orbital history of this debris would enable us to self-consistently link planetary system formation and fate.
Scheeres, Daniel J, Veras, Dimitri
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source