Results 221 to 230 of about 1,553,048 (247)

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Evaluation of stream visual assessment protocol with measured water quality parameters in urban streams. [PDF]

PLoS One
McMurray C, Finch AC, Jones K, Keaton E, Parkinson H, Patterson N, James J, Burkholder J, Meza-Salazar A, McKenney EA.   +9 more
europepmc   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

<i>Aspergillus</i> Infection of a Postoperative Thoracic Cavity. [PDF]

Respirol Case Rep
Sugino M, Kusaba Y, Nagano M, Izumi S.
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Oral Health and Quality of Life in Patients With Schizophrenia in Remission-A Call for Integration Within Special Care Dentistry. [PDF]

Spec Care Dentist
Ghai VK.
europepmc   +1 more source

Orthopedic implant allergies: a review of current knowledge on metal hypersensitivity and prosthesis failure. [PDF]

EFORT Open Rev
Viola V, Marelli N, Caplanusi T, Steinmetz S.   +3 more
europepmc   +1 more source

Multi-technology Detection of Undocumented Orphaned Oil and Gas Wells: A Large-Scale Drone and Ground-Based Survey in Pennsylvania. [PDF]

Environ Sci Technol
Boutot J, France JL, Coleman M, Peltz AS, Keown N, Hegburg D, Adams D, Ciulla F, Biraud SC, Kohnke C, Pekney NJ, Thomas WH, Fox-Coughlin V, Ding G, Mailhot Z, Boumenna Y, Jahan I, Mehana M, Viswanathan H, Kang M.   +19 more
europepmc   +1 more source

Amplified Arctic iceberg traffic reshapes benthic biodiversity. [PDF]

Nature
Krumpen T, Meyer-Kaiser KS, Wekerle C, Ackermann L, Castle D, Bergmann M, Hoppmann M, Khan SA, Purser A, Schmithüsen H.   +9 more
europepmc   +1 more source

Mixed Invasive Fungal Pneumonia Caused by <i>Aspergillus</i>, <i>Candida</i>, <i>Mucor</i> in an Immunocompromised Host. [PDF]

Respirol Case Rep
Kim T, Jung E, Jeon Y, Choi H, Lee HS, Jang TW, Oak CH.   +6 more
europepmc   +1 more source