Results 71 to 80 of about 5,916 (262)

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Reduction and Archiving of Multiwavelength, Polarized-intensity Debris-disk Observations with the Gemini Planet Imager

The Astrophysical Journal Supplement Series
The Gemini Planet Imager (GPI), an extreme adaptive optics instrument on Gemini South, has been pivotal in the advancement of the debris-disk field.
Katie A. Crotts, Thomas M. Esposito, Brenda C. Matthews, Gaspard Duchêne, Christine H. Chen, Justin Hom, Paul Kalas, Briley L. Lewis, Stanimir Metchev, Maxwell Millar-Blanchaer, Deborah Padgett, Marshall Perrin, Bin Ren   +12 more
doaj   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Debris Disks Can Contaminate Mid-infrared Exoplanet Spectra: Evidence for a Circumstellar Debris Disk around Exoplanet Host WASP-39

The Astrophysical Journal Letters
The signal from a transiting planet can be diluted by astrophysical contamination. In the case of circumstellar debris disks, this contamination could start in the mid-infrared and vary as a function of wavelength, which would then change the observed ...
Laura Flagg, Alycia J. Weinberger, Taylor J. Bell, Luis Welbanks, Giuseppe Morello, Diana Powell, Jacob L. Bean, Jasmina Blecic, Nicolas Crouzet, Peter Gao, Julie Inglis, James Kirk, Mercedes López-Morales, Karan Molaverdikhani, Nikolay Nikolov, Apurva V. Oza, Benjamin V. Rackham, Seth Redfield, Shang-Min Tsai, Ray Jayawardhana, Laura Kreidberg, Matthew C. Nixon, Kevin B. Stevenson, Jake D. Turner   +23 more
doaj   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

High Resolution ALMA Data of the Fomalhaut Debris Disk Confirms Apsidal Width Variation

The Astrophysical Journal Letters
We present long-baseline observations of the Fomalhaut outer debris disk at 223 GHz (1.3 mm) from Atacama Large Millimeter/submillimeter Array (ALMA) Cycle 5, which we use along with archival short-baseline observations to produce a 0 $\mathop{.}\limits{^
Jay S. Chittidi, Meredith A. MacGregor, Joshua Bennett Lovell, Gaspard Duchene, Mark Wyatt, Olja Panic, Paul Kalas, Margaret Pan, A. Meredith Hughes, David J. Wilner, Grant M. Kennedy, Luca Matrà, Michael P. Fitzgerald, Kate Y. L. Su   +13 more
doaj   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

A JWST MIRI MRS View of the η Tel Debris Disk and Its Brown Dwarf Companion

The Astrophysical Journal
We report JWST Mid-Infrared Instrument (MIRI) Medium Resolution Spectrograph (MRS) observations of the β Pic moving-group member, η Tel A, along with its brown dwarf binary companion, η Tel B.
Yiwei Chai, Christine H. Chen, Kadin Worthen, Alexis Li, Antranik A. Sefilian, William Balmer, Dean C. Hines, David R. Law, B. A. Sargent, Mark Wyatt, Cicero X. Lu, Marshall D. Perrin, Isabel Rebollido, Emily Rickman, G. C. Sloan   +14 more
doaj   +1 more source