Results 91 to 100 of about 292,207 (238)

Evaluation of Apical Extrusion of Debris with Tactile Controlled Activation Technique Using Controlled Memory Files in Curved Root Canals: An in vitro Study

Journal of Pharmacy and Bioallied Sciences
Background and Objectives: The purpose of the study was to quantify the amount of debris that was extruded apically when single-length and tactile controlled activation (TCA) techniques were used to instrument curved canals.
Drisya D. Nambiar, Gurudutt Nayak, A. R. Vivekananda Pai, Ojaswini Pawar, Sonam Bohra, Gopal C. Sanyal, Mudassir Khan   +6 more
doaj   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Comparison of Apical Extrusion of Debris by Using Single-File, Full-Sequence Rotary and Reciprocating Systems

Frontiers in Dentistry, 2017
Objectives: During root canal preparation, apical extrusion of debris can cause inflammation, flare-ups, and delayed healing. Therefore, instrumentation techniques that cause the least extrusion of debris are desirable. This study aimed to compare apical
Maryam Ehsani, Robab Farhang, Azadeh Harandi, Saeid Tavanafar, Maryam Raoof, Saeedeh Galledar   +5 more
doaj  

Apical extrusion of debris and irrigants using different irrigation needles

, 2016
This study evaluated the influence of irrigation tip, root canal curvature and final apical diameter on periapical debris and irrigant extrusion during root canal instrumentation.
Silva, Paula Barcellos, Leonardo, Renato de Toledo [UNESP], Casarin, Renata Picanço, Leonardo, Renato de Toledo, Lima, Regina Karla Pontes, Krolow, Angélica Mohnsam, Pappen, Fernanda Geraldo, Pilownic, Katerine Jahnecke, Lima, Regina Karla Pontes [UNESP]   +8 more
core   +1 more source

Rheology of semi-solid fresh cement pastes and mortars in orifice extrusion [PDF]

, 2013
Short fiber-reinforced semi-solid fresh cement pastes and mortars, tailored for extrusion, have much lower water-to-binder ratio and higher viscosity than normal cement pastes or mortars. The rheology of these pastes or mortars cannot be characterized by
Fan, Mizi, Li, Zongjin, Li, Z, Zhou, Xiangming, Zhou, X, Fan, M, Chen, HuaPeng, Chen, H   +7 more
core   +1 more source

Dual Suppression of Oxidative Stress and JAK/STAT3 Signaling Attenuates Inflammation‐Driven Corneal Neovascularization

Advanced Science, EarlyView.
Corneal neovascularization is sustained by oxidative stress and inflammatory STAT3 signaling. A macrophage membrane‐cloaked nanozyme, Sta@MSR, combines ruthenium‐mediated ROS scavenging with Stattic‐mediated STAT3 inhibition. Delivered as eye drops, Sta@MSR enhances ocular retention and corneal penetration, reduces inflammatory and angiogenic responses,
Qinghua Li, Ruoxi Li, Bingxin Ren, Chaoya Gong, Hui Yan, Jie Chen, Benzhao Fu, Chaoqun Wei, Qingdong Bao, Yang Li, Xiaoxue Liu, Wenlong Li, Hua Gao   +12 more
wiley   +1 more source

Comparative evaluation of debris extruded apically by using, Protaper retreatment file, K3 file and H-file with solvent in endodontic retreatment

Saudi Endodontic Journal, 2012
Aim: The aim of this study was to evaluate the apical extrusion of debris comparing 2 engine driven systems and hand instrumentation technique during root canal retreatment.
Chetna Arora, Rohit Bahri, Neelam Mittal
doaj   +1 more source

Microenvironment‐Responsive Biomimetic Hydrogels Delivering Cistanche Deserticola‐Derived Nanovesicles for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
An injectable, microenvironment‐responsive hydrogel (HAPOCS@CDNVs) is developed for sustained delivery of Cistanche deserticola‐derived nanovesicles (CDNVs). By scavenging ROS, restoring mitochondrial function, and attenuating SASP, this platform effectively suppresses nucleus pulposus cell senescence and facilitates extracellular matrix reconstruction,
Ning Xu, Xiaoyu Cai, Xiaofu Tang, Weidong Liang, Linsong Teng, Yudong Jing, Haifeng Hu, Yuhao Duan, Mingjie Kuang, Lei Zhang, Shijie Han, Weibin Sheng   +11 more
wiley   +1 more source