Results 51 to 60 of about 12,835 (293)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Hungarian Studies YearbookFor most of the 20th century, Hungarian literary history disregarded decadence as a thematic or stylistic marker and refused to acknowledge that it was a significant cultural driving force of the fin-de-siècle Hungarian literature. I propose to interpret
Tőtős Dorottya
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
‘A sort of breviary’: Arthur Symons, J. K. Huysmans and British Decadence
Cahiers Victoriens et Edouardiens, 2019 Arthur Symons’s description of J. K. Huysmans’s À rebours as ‘the breviary of decadence’ is widely cited by critics. It has had a significant influence on our understanding of Huysmans and upon histories of the Decadent movement more generally.
Matthew Creasy
doaj +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
Decadence and Performance: Full Issue [PDF]
, 2021 Volupté 4.2, Decadence and Performance: Full ...
Alston, Adam, Bickley Trott, Alexandra
core +1 more source
‘Queer Reverence’: Aubrey Beardsley’s Venus and Tannhäuser
Cahiers Victoriens et Edouardiens, 2019 During his short career, the writer and artist Aubrey Beardsley, who rose to prominence in the 1890s, cultivated a reputation for mannered excess that helped establish him as one of the aesthetes and decadents whose company he kept and whose works he ...
Nicole Fluhr
doaj +1 more source