Results 101 to 110 of about 34,142 (307)

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Effect of test related factors on the degradation of cement-based materials on acetic acid exposure

Materials Research Express
Exposure of concrete to various acids can hardly be overstated due to the widespread use of concrete in the construction industry. The effect of selected factors on the degradation of ordinary Portland cement (OPC 53 grade) paste and mortar exposed to ...
Chinnu Mariam Ninan, Ramaswamy K P, Alexandra Bertron, Sajeeb R   +3 more
doaj   +1 more source

Bamboo‐Like Whiskers‐Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type‐H Vessels and Osteoinduction

Advanced Science, EarlyView.
The graphical abstract image of bamboo‐like whisker‐reinforced Ca‐P bioceramics accelerating large segmental bone regeneration. ABSTRACT Regenerative repair of segmental bone defect remains a major clinical challenge. The conventional mental implants suffer from mechanical strength mismatch and long‐term foreign bodies presence.
Cong Feng, Haibo Teng, Chuyao Xu, Jiaze He, Keting Liu, Xueying Li, Kai Zhang, Xiangdong Zhu, Xiangfeng Li, Jianguo Xu, Xingdong Zhang   +10 more
wiley   +1 more source

Prevalence of White Spot Lesions during Orthodontic Treatment [PDF]

, 2009
The reported prevalence of decalcification in orthodontic patients varies from 2 to 96% mainly due to the lack of a standard examination technique. The aims of this study were: 1) to determine the prevalence of white spot lesions around brackets using ...
Dixon, Julian
core   +1 more source

Three-dimensional histological specimen preparation for accurate imaging and spatial reconstruction of the middle and inner ear [PDF]

, 2013
PURPOSE:    This paper presents a highly accurate cross-sectional preparation technique. The research aim was to develop an adequate imaging modality for both soft and bony tissue structures featuring high contrast and high resolution.
Omid Majdani, Thomas Lenarz, Thomas S. Rau, Waldemar Würfel   +3 more
core   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Impact of a 70°C temperature on an ordinary Portland cement paste/claystone interface: An in situ experiment

, 2016
International audienceRadioactive wastes in future underground disposal sites will induce a temperature increase at the interface between the cementitious materials and the host rock. To understand the evolution of Portland cement in this environment, an
Barnichon, Jean-Dominique, Bartier, Danièle, Dauzères, Alexandre, de Windt, Laurent, Detilleux, Valéry, Lalan, Philippines, Sammaljärvi, Juuso, Techer, Isabelle   +7 more
core   +3 more sources

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Sediment structure and physicochemical changes following tidal inundation at a large open coast managed realignment site [PDF]

, 2018
Managed realignment (MR) schemes are being implemented to compensate for the loss of intertidal saltmarsh habitats by breaching flood defences and inundating the formerly defended coastal hinterland.
Andrew B. Cundy, Auxtero, Bergen, Berrow, Beven, Bone, Burton, Cnudde, Cochran, Cope, Costanza, Crooks, Crooks, Croudace, Cundy, Cundy, Cundy, Cundy, Dale, Dale, Dale, David J. Nash, Davy, Doherty, Doody, Elliott, Environment Agency, Erfanzadeh, Esteves, European Parliament and the Council of the European Commission, Foster, French, Hazelden, Heidi M. Burgess, Howe, Hvorslev, Ian W. Croudace, Johnston, Jonathan Dale, Kate L. Spencer, Ketcham, Koretsky, Krawiec, Luther, Marani, Mazik, Miller, Moller, Mossman, Odgaard, Pearce, Polder, Reid, Rowell, Rupprecht, Shennan, Shennan, Simon J. Carr, Spencer, Spencer, Spencer, Tempest, Violante, Vogel, Vranken, Watts, Wilson, Wolanski, Zwolsman   +68 more
core   +3 more sources

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source