Results 141 to 150 of about 21,128 (261)

AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model

open access: yesSensory Neuroscience, EarlyView.
Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou   +6 more
wiley   +1 more source

Cold‐curing effects on the strength development and sulfuric acid resistance of basalt fiber‐reinforced hybrid alkali‐activated slag mortars

open access: yesStructural Concrete, EarlyView.
Abstract Cold weather conditions impose substantial constraints upon the performance and long‐term resilience of concrete materials. Alkali‐activated slag (AAS) presents itself as a promising substitute, exhibiting sustained hydraulic activity even when exposed to ambient conditions characterized by low temperatures.
Zeynep Bahçeci   +3 more
wiley   +1 more source

Mechanical, rheological, and durability performances of GGBS‐based concrete for potential application to prestressed structures

open access: yesStructural Concrete, EarlyView.
Abstract Ground granulated blast‐furnace slag (GGBS) is a widely used clinker substitute in concrete, recognized for its potential to significantly reduce environmental impacts. However, its application in prestressed concrete remains limited in several countries, mainly due to concerns regarding early‐age mechanical performance and long‐term ...
D. Rolando Baldiviezo   +6 more
wiley   +1 more source

Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An   +7 more
wiley   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda   +6 more
wiley   +1 more source

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