Results 41 to 50 of about 308,696 (151)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Práctica del intelectual más allá del saber: Lyotard, Foucault, Blanchot
Isegoría, 2018 En el presente artículo abordamos diferentes interpretaciones críticas de la figura y la labor del intelectual. Partimos del análisis de Lyotard sobre el declive de los parámetros universalistas y la consiguiente desaparición de la figura del intelectual
Idoia Quintana Domínguez
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Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Revista Chilena de Salud PúblicaIntroducción: En el año 2017 es promulgada en Chile la ley de Interrupción Voluntaria del Embarazo en tres causales, teniendo como eje central la decisión de la mujer.
Haylyn Sarria Cárcamo
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Carl Schmitt, "Teórico" de la Constitución de Weimar
Pensamiento. Revista de Investigación e Información Filosófica, 2017 Impensable obviar la polémica figura de Carl Schmitt en el actual debate teórico en torno a la cuestión política y el modo de organizar un Estado. En el presente texto exploramos la relación de Carl Schmitt con el proceso de constitución de la República ...
Francisco Serra Giménez
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Thēmis, 2020 En el presente artículo el autor analiza los alcances e interrelación existente entre los conceptos de acuerdo, decisión, recomendación y práctica concertada a la luz de la doctrina y jurisprudencia comparada, tomando especial consideración en la ...
Waldo Borda Gianella
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