Results 181 to 190 of about 2,669,087 (263)

Updated International Patient Decision Aid Standards (IPDAS version 5.0): modified Delphi, evidence informed consensus process.

BMJ
Volk RJ, Lewis KB, Smith M, Carley M, Barry MJ, Bekker HL, Härter M, Hoffmann T, McCaffery K, Pignone M, Steffensen KD, Sepucha K, Thompson R, Trevena L, van der Weijden T, Witteman HO, Stacey D.   +16 more
europepmc   +1 more source

An intuitive sampling framework for setting-specific decision-making in soil-transmitted helminthiasis control programs. [PDF]

PLoS Negl Trop Dis
Kazienga A, Levecke B, de Vlas SJ, Coffeng LE.   +3 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Quantitative Medicine to Support Drug Development and Regulatory Decisions: A UK Regulatory Approach Informed by ICH M15. [PDF]

Clin Transl Sci
Kerwash E, Butler AS, Malamatari M, Cole S.   +3 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Shared Decision Making: Aids and Promotion in Clinical Practice Guidelines for Type 2 Diabetes Treatment. [PDF]

J Eval Clin Pract
Vincent YM, Kasbi M, Saouli R, Clara B, Boussageon R.   +4 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The Six R's of Management Reasoning for Subintern Education. [PDF]

Clin Teach
Maldonado M, Boedeker P, Kusnoor AV.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source