Results 1 to 10 of about 689,510 (268)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Decision Analysis = Decision Engineering [PDF]

, 2005
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Aiding clinical decisions with decision analysis

Hospital Medicine, 1999
As clinical decision making gets ever more complex, new analytical approaches are being developed to help. Decision analysis is used to structure complex decision problems in an uncertain environment by systematically linking decision choices with expected outcomes.
Tavakoli M, Davies HTO, Thomson R
openaire   +2 more sources

Characteristics of Decisions in Decision Analysis Practice

Journal of the Operational Research Society, 1995
Summary: This paper presents summary statistics regarding the characteristics of decisions identified in a recent review of 86 applications of decision analysis. The goals of this summary are (1) to identify values for important parameters which characterize the structure of decisions which have been analyzed using decision analysis; (2) to see what ...
Corner, James L., Corner, Patricia D.
openaire   +1 more source

Decision Tables and logic in Decision Analysis

Medical Decision Making, 1986
Unmanageably bushy decision trees result when a decision analysis involves several in vestigations. They can be simplified for riskless tests by deriving the maximum expected utility decision table for the problem as an intermediate step. This table can be logically summarized as Boolean expressions involving the tests.
Glasziou, Paul, Hilden, Jörgen
openaire   +4 more sources

Decision Analysis in a Corporation

IEEE Transactions on Systems Science and Cybernetics, 1968
The practical advantage of decision analysis is the decomposition of a complex problem into simpler parts that it makes possible. The consequences of a decision can be described in terms of contingent payoffs and then evaluated via independently assessed risk preferences (codified in a utility measure) and likelihood judgments (codified in a ...
openaire   +2 more sources

Decision Analysis in Formulary Decision Making

PharmacoEconomics, 1993
Although decision making about what drugs to include in an institutional formulary appears to lend itself readily to quantitative techniques such as decision analysis and cost-benefit analysis, a review of the literature reveals that very little has been published in this area.
openaire   +2 more sources