Results 111 to 120 of about 26,255,985 (305)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Epistasis-aware genome-wide association studies provide insights into the efficient breeding of high-yield and high-quality rice

Journal of Integrative Agriculture
Marker-assisted selection (MAS) and genomic selection (GS) breeding have greatly improved the efficiency of rice breeding. Due to the influences of epistasis and gene pleiotropy, ensuring the actual breeding effect of MAS and GS is still a difficult ...
Xiaogang He, Zirong Li, Sicheng Guo, Xingfei Zheng, Chunhai Liu, Zijie Liu, Yongxin Li, Zheming Yuan, Lanzhi Li   +8 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Polygyny and Intrahousehold Decision-making: EPAR Project #330 [Stata .do files]

, 2017
<p>Initial release of 330_Polygyny-and-Intrahousehold-Decision-making repository. This analysis is part of EPAR Technical Report #330: Polygynous Households and Intrahousehold Decision-Making: Evidence and Policy Implications from Mali and ...
Evans School Policy Analysis & Research Group (EPAR)
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Sequential action and beliefs under partially observable DSGE environments [PDF]

, 2012
Revised and resubmitted at Computational EconomicsThis paper introduces a classification of DSGEs from a Markovian perspective, and positions the class of POMDP (Partially Observable Markov Decision Process) to the center of a generalization of linear ...
Kim, Seong-Hoon
core   +1 more source

Topological Derivative-Based Topology Optimization of Linearized Viscous Shallow Water Equation

International Journal of Mathematics and Mathematical Sciences
In this paper, we focus on the derivation of the topological derivative of shallow water equations. We consider two-dimensional viscous shallow-water equations linearized around a constant velocity.
Mame Gor Ngom, Bakary Kourouma, Ibrahima Faye, Diaraf Seck   +3 more
doaj   +1 more source

On Ordinal Information-Based Weighting Methods and Comparison Analyses

Information
In this paper, we focus on weighting methods within multi-attribute utility/value theory (MAUT/MAVT). In these methods, the decision maker (DM) provides ordinal information about the relative importance of criteria, but also additional information ...
Zhor Chergui, Antonio Jiménez-Martín
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Decision Pattern Analysis as a General Framework for Studying Individual Differences in Decision Making

, 2016
This paper investigated decision pattern analysis (DPA) as a general and standard framework for studying individuals' consistent decision making behavior within and between contexts.
Stankov, Lazar, Pauline Howie, Howie, Pauline, Simon A. Jackson, Sabina Kleitman, Lazar Stankov, Jackson, Simon A., Kleitman, Sabina   +7 more
core   +1 more source