Results 251 to 260 of about 33,007,624 (364)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Comparison of open fetal, fetoscopic and postnatal surgical repair for open spina bifida: decision analysis. [PDF]

Ultrasound Obstet Gynecol
Kunpalin Y, Sahakyan Y, Sander B, Snelgrove JW, Raghuram K, Kulkarni AV, Van Mieghem T.   +6 more
europepmc   +1 more source

An analysis of decision making and criminal outcomes in sexual offenders

, 2015
Amélie Pedneault
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

SMART Multi-Criteria Decision Analysis (MCDA)-One of the Keys to Future Pandemic Strategies. [PDF]

J Clin Med
Băcescu Ene GV, Stoia MA, Cojocaru C, Todea DA.   +3 more
europepmc   +1 more source

The spectrum of behaviour and decisions of clinical officers; an analysis of decisions made by clinical officers at the Government Hospital, Kiambu, Kenya.

, 1976
Vogel Lc, W Swinkels, Sjoerdsma Ac
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Multicriteria Decision Analysis of the Influence of Natural Fibers on the Flexibility of Renewable Polyurethane Composites. [PDF]

Materials (Basel)
Cardoso E, Escócio V, Infante C, Pacheco E.   +3 more
europepmc   +1 more source

The Skybolt Missile Cancellation: An Analysis of Foreign Policy Decision Making in the Kennedy Executive

, 1995
Barry G. Webb
openalex   +1 more source

From cradle-to-grave at the nanoscale : expert risk perceptions, decision-analysis, and life cycle regulation for emerging nanotechnologies

, 2013
Christian Earl Henry Beaudrie
openalex   +1 more source