Results 71 to 80 of about 65,002 (306)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Decomposition Based on Decision Diagrams [PDF]
, 2016 In recent years, decision diagrams (DDs) have proven useful for solving a variety of optimization problems, often closing long-standing instances from classical benchmarks. This success is primarily driven by a DDs ability to capture structure. This paper exploits this characteristic and proposes a novel solution method which decomposes a problem into ...
David Bergman, André A. Ciré
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Applied SciencesDecision trees are a widely used machine learning technique due to their ease of interpretation and construction. This method allows domain experts to learn from raw data, but they cannot include their prior knowledge in the analysis due to its automatic
Miguel A. Mohedano-Munoz +2 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A Recursive Framework for Evaluating Moments Using Zero-Suppressed Binary Decision Diagrams
IEEE AccessThe zero-suppressed binary decision diagram (ZDD) is a compact data structure widely used for the efficient representation of families of sparse subsets.
Brian Godwin Lim +4 more
doaj +1 more source
The role of time in influence diagrams
Journal of Telecommunications and Information Technology, 2003 An influence diagram is a compact representation emphasizing the qualitative features of decision problem under uncertainty. Classical influence diagram has parameters stable in time, determined order of suggested decisions and generally is independent ...
Wiesław Traczy
doaj +1 more source
AbsSynthe: abstract synthesis from succinct safety specifications [PDF]
Electronic Proceedings in Theoretical Computer Science, 2014 In this paper, we describe a synthesis algorithm for safety specifications described as circuits. Our algorithm is based on fixpoint computations, abstraction and refinement, it uses binary decision diagrams as symbolic data structure.
Romain Brenguier +3 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source