Results 141 to 150 of about 7,287,755 (306)

How do financial considerations influence medical decision-making? A qualitative-empirical study in German cancer medicine. [PDF]

BMJ Public Health
König JFL, Aufenberg B, Brei G, Reitmayer S, Sommerlatte S, Greiner W, Schildmann J, Winkler EC, Mehlis K.   +8 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

From prediction to action-Making emergency laparotomy risk scores clinically usable. [PDF]

Surg Pract Sci
Vijayaraghavalu S.
europepmc   +1 more source

Polynomial-time implication problems for unary inclusion dependencies

JACM, 1990
S. Cosmadakis, P. Kanellakis, Moshe Y. Vardi   +2 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Case of Two Pulmonary Arteries in a Child with Sinus Venosus Atrial Septal Defect. [PDF]

Ann Card Anaesth
Suvetha S, Munaf M.
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Improving Reporting of Withdrawal of Life-Sustaining Treatment in Acute Brain Injury Trials: A Methodologic Imperative. [PDF]

Am J Respir Crit Care Med
Taran S, Turgeon AF, Steinberg A, Adhikari NKJ.   +3 more
europepmc   +1 more source

Implications for Decisions Concerning Grazing Fees

, 1968
Studies of the grazing fee problem by western universities and government agencies have focused on the economic and welfare implications of changes in grazing fee policy. Ignored in these studies are the problems of ethics and legal precedent. This paper examines (1) the theory and practice of handling real property and (2) legal precedent as they ...
openaire   +1 more source

CREW PRAMS and decision trees

Symposium on the Theory of Computing, 1989
N. Nisan
semanticscholar   +1 more source