The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang+9 more
wiley +1 more source
Modeling multistage decision processes with Reflexive Game Theory [PDF]
This paper introduces application of Reflexive Game Theory to the matter of multistage decision making processes. The idea behind is that each decision making session has certain parameters like "when the session is taking place", "who are the group members to make decision", "how group members influence on each other", etc.
arxiv
Decision making with decision event graphs [PDF]
We introduce a new modelling representation, the Decision Event Graph (DEG), for asymmetric multistage decision problems. The DEG explicitly encodes conditional independences and has additional significant advantages over other representations of ...
Cowell, Robert G.+2 more
core
A combined compromise solution (CoCoSo) method for multi-criteria decision-making problems
PurposeThe purpose of this paper is to discuss the advantage of a combinatory methodology presented in this study. The paper suggests that the comparison with results of previously developed methods is in high agreement.Design/methodology/approachThis ...
M. Yazdani+3 more
semanticscholar +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka+6 more
wiley +1 more source
Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III
During perceptually guided decisions, correlates of choice are found as upstream as in the primary sensory areas. However, how well these choice signals align with early sensory representations, a prerequisite for their interpretation as feedforward ...
Pierre-Marie Gardères+5 more
doaj +1 more source
Learning from Evolution: Improving Collective Decision-Making Mechanisms using Insights from Evolutionary Robotics [PDF]
Collective decision-making enables multi-robot systems to act autonomously in real-world environments. Existing collective decision-making mechanisms suffer from the so-called speed versus accuracy trade-off or rely on high complexity, e.g., by including global communication.
arxiv +1 more source
Selection of Tunnel Support System by Using Multi Criteria Decision-Making Tools [PDF]
Selection of the optimum support system for underground openings such as tunnels is a complex process. In this paper, a new approach, based on a combination of the Analytical Hierarchy Process (AHP), the Technique for Order Preference by Similarity to ...
Gholinejad, Mehran+2 more
core
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten+10 more
wiley +1 more source
The role of chronic pain and pain anxiety in delay discounting of pain and monetary losses
Pain may alter intertemporal decisions by modifying the value of pain-related outcomes. For example, a person with chronic back pain may be faced with two choices: undergo surgery that could provide long-term relief but would involve additional short ...
Wojciech Białaszek+3 more
doaj +1 more source