Results 101 to 110 of about 12,156,070 (400)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Analogy in Decision Making [PDF]

Mathematics of Operations Research, 2015
In the context of decision making under uncertainty, I formalize the concept of analogy: an analogy between two decision problems is a mapping that transforms one problem into the other while preserving the problem’s structure. After identifying the basic structure of a decision problem, I introduce the concepts of analogical reasoning operator and of
openaire   +3 more sources

Decision-aid or Controller? Steering Human Decision Makers with Algorithms [PDF]

arXiv, 2023
Algorithms are used to aid human decision makers by making predictions and recommending decisions. Currently, these algorithms are trained to optimize prediction accuracy. What if they were optimized to control final decisions? In this paper, we study a decision-aid algorithm that learns about the human decision maker and provides ''personalized ...
arxiv  

Decision-making by expectant parents: NIPT, NIPD, and current methods of prenatal screening for Down’s Syndrome (Evidence Review) [PDF]

, 2017
The objective of this review is to examine research exploring the decisions that women and couples make about prenatal screening and testing and the factors that influence their decisions.
Thomas, Gareth
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

The effectiveness of a de-implementation strategy to reduce low-value blood management techniques in primary hip and knee arthroplasty: a pragmatic cluster-randomized controlled trial

Implementation Science, 2017
Background Perioperative autologous blood salvage and preoperative erythropoietin are not (cost) effective to reduce allogeneic transfusion in primary hip and knee arthroplasty, but are still used.
Veronique M. A. Voorn, Perla J. Marang-van de Mheen, Anja van der Hout, Stefanie N. Hofstede, Cynthia So-Osman, M. Elske van den Akker-van Marle, Ad A. Kaptein, Theo Stijnen, Ankie W. M. M. Koopman-van Gemert, Albert Dahan, Thea P. M. M. Vliet Vlieland, Rob G. H. H. Nelissen, Leti van Bodegom-Vos   +12 more
doaj   +1 more source

Reframing the EU budget- decision-making process [PDF]

This paper traces the history of the EU budget and draws lessons for the review to come. Whatever reforms are proposed, the authors believe that they must serve to shift spending to policy areas and instruments where the EU can best add value while at ...
Indhira Santos, Susanne Neheider
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

DISCERN: Designing Decision Support Interfaces to Investigate the Complexities of Workplace Social Decision-Making With Line Managers [PDF]

Line managers form the first level of management in organizations, and must make complex decisions, while maintaining relationships with those impacted by their decisions. Amidst growing interest in technology-supported decision-making at work, their needs remain understudied.
arxiv   +1 more source

Weighting methods for multi-criteria decision making technique

Journal of Applied Sciences and Environmental Management, 2019
Determining criteria weights is a problem that arises frequently in many multi-criteria decision-making (MCDM) techniques. Taking into account the fact that the weights of criteria can significantly influence the outcome of the decision-making process ...
G. Odu
semanticscholar   +1 more source