Results 101 to 110 of about 11,731,529 (403)
Decision-aid or Controller? Steering Human Decision Makers with Algorithms [PDF]
arXiv, 2023 Algorithms are used to aid human decision makers by making predictions and recommending decisions. Currently, these algorithms are trained to optimize prediction accuracy. What if they were optimized to control final decisions? In this paper, we study a decision-aid algorithm that learns about the human decision maker and provides ''personalized ...
arxiv
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Analogy in Decision Making [PDF]
Mathematics of Operations Research, 2015 In the context of decision making under uncertainty, I formalize the concept of analogy: an analogy between two decision problems is a mapping that transforms one problem into the other while preserving the problem’s structure. After identifying the basic structure of a decision problem, I introduce the concepts of analogical reasoning operator and of
openaire +3 more sources
FEBS Letters, EarlyView.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
Implementation Science, 2017 Background Perioperative autologous blood salvage and preoperative erythropoietin are not (cost) effective to reduce allogeneic transfusion in primary hip and knee arthroplasty, but are still used.
Veronique M. A. Voorn +12 more
doaj +1 more source
Decision-making on shared sanitation in the informal settlements of Kisumu, Kenya. [PDF]
, 2017 Unlike most quantitative studies that investigate decision-making on investing in sanitation, this study adopted a qualitative approach to investigate decision-making on shared sanitation in the informal settlements of Kisumu city, in Kenya.
Cairncross, Sandy +2 more
core +1 more source
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
DISCERN: Designing Decision Support Interfaces to Investigate the Complexities of Workplace Social Decision-Making With Line Managers [PDF]
Line managers form the first level of management in organizations, and must make complex decisions, while maintaining relationships with those impacted by their decisions. Amidst growing interest in technology-supported decision-making at work, their needs remain understudied.
arxiv +1 more source
Reframing the EU budget- decision-making process [PDF]
This paper traces the history of the EU budget and draws lessons for the review to come. Whatever reforms are proposed, the authors believe that they must serve to shift spending to policy areas and instruments where the EU can best add value while at ...
Indhira Santos, Susanne Neheider
core +1 more source
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source