Results 81 to 90 of about 1,432,942 (247)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Translation and cultural adaption of Observer OPTION5 and OPTION12 in a Danish context

Health Literacy and Communication Open
Background and aim The aim of this study was to translate and culturally adapt the Observer scales OPTION5 and OPTION12 into Danish to improve the accessibility of the scales for all healthcare professionals and patients as co-researchers to objectively ...
Bettina Mølri Knudsen, Karina Olling, Karina Dahl Steffensen   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Motor resonance and inhibitory mechanisms in action observation as revealed by corticospinal excitability

Scientific Reports
Motor resonance (MoR) refers to the automatic activation of motor circuits during action observation, reflecting an internal simulation of the observed movement.
Carlos Nieto-Doval, Aynur Ragimova, Gleb Perevoznyuk, Traian Popa, Oleg Shevtsov, Victoria Moiseeva, Matteo Feurra   +6 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Whoever wants better healthcare simply pays more: citizens' perception about voluntary private health insurance in Colombia

International Journal for Equity in Health
Objectives To explore the perceptions that Colombians have about voluntary private health insurance plans (VPHI) in the health system to identify the tensions that exist between the public and private systems.
Daniel Felipe Patiño-Lugo, Claudia Marcela Vélez, Diana Patricia Díaz-Hernández, Olga Francisca Salazar-Blanco, Juan Esteban González-Arango, Juan Carlos Velásquez-Correa, Leydi Camila Rodríguez-Corredor, Viviana María Vélez-Marín, Pamela Velásquez-Salazar   +8 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Digital finance, industrial structure upgrading, and energy efficiency in China: a provincial-level empirical analysis

Humanities & Social Sciences Communications
During China’s critical period of industrial structural transformation, the relationship between digital finance, industrial structure upgrading, and energy efficiency has become a crucial issue that urgently requires exploration in the process of ...
Haicheng Zhu, Xingyu Qi, Minghao Xu, Jian Su, Zerong Wang   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source