Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Advancing AI-based clinical decision support for complex interventions requires an operationalized framework. [PDF]
Pain RepÄng B +9 more
europepmc +1 more source
Group Decision Support System based on AHP-TOPSIS for Culinary Recommendation System
, 2019 Ratih Kartika Dewi
openalex +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Heart Rate Variability-Derived Decision Support Tool for Prognostication in Emergency Department Patients With Suspected Infection. [PDF]
Biomed Res IntSeely AJE +8 more
europepmc +1 more source
Reliability Evaluation and Decision Support System of a Pharmaceutical Plant
, 2010 Deepika Bansal +2 more
openalex +1 more source
Improvements in Data Quality for Decision Support in Intensive Care
, 2011 Filipe Portela +2 more
openalex +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Critical impact of automobile industry with advanced decision support system and Aczél-Alsina Hammy mean operators. [PDF]
Sci RepHussain A, Ullah K, Ali Z, Pamucar D.
europepmc +1 more source
Modelling of investment decisions on technical support of agricultural enterprises
, 2017 Ludmila Smoliy +2 more
openalex +1 more source