Results 191 to 200 of about 1,928,942 (329)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Smart ICUs: The Role of Artificial Intelligence in Modern Intensive Care Units. [PDF]

Cureus
Singh N.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The regulation of artificial intelligence in intensive care units: from narrow tools to generalist systems. [PDF]

NPJ Digit Med
Freyer O, Mathias R, Muti HS, Orlovsky H, Buch S, Ostermann M, Schönfelder A, Poncette AS, Bassily-Marcus A, Gilbert S.   +9 more
europepmc   +1 more source

Clinical Decision Support System Sonares

, 2008
A decision support system SonaRes destined to guide and help the ultrasound operators is proposed and compared with the existing ones. The system is based on rules and images and can be used as a second opinion in the process of ultrasound examination.
Cojocaru, Svetlana, Gaindric, Constantin
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Research progress on the application of machine learning clinical decision support system in ICU

Huli yanjiu
This paper reviewed the relevant researches on the application of machine learning clinical decision support system in ICU from four aspects:overview,application status,challenges and future development trends,aiming to enhance the intelligent management
YAN Huina, LIU Ruiyun, LI Ying, DAI Jinghua, WANG Jiaxun, ZHAO Min, LU Jiayun   +6 more
doaj  

Clinical Artificial Intelligence Agents in Nephrology: From Prediction to Action Through Workflow-Native Intelligence-A Roadmap for Workflow-Integrated Care. [PDF]

J Clin Med
Thongprayoon C, Pesce F, Cheungpasitporn W.   +2 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Comparison of OneChoice AI-based clinical decision support recommendations with infectious disease specialists and non-specialists for bacteremia treatment in Lima, Peru. [PDF]

PLoS One
Gómez de la Torre JC, Frenkel A, Chavez-Lencinas C, Rendon A, Fabian M, Caceres-DelAguila JA, Hueda-Zavaleta M.   +6 more
europepmc   +1 more source