Results 291 to 300 of about 1,169,808 (377)

Depth‐Dependence Changes in Soil Stoichiometry in China's Croplands Over the Past Four Decades

open access: yesAdvanced Science, EarlyView.
This study reveals depth‐dependent changes in soil C:N:P ratios across Chinese croplands over four decades. Changes in stoichiometry vary markedly between topsoil and subsoil, with initial soil C:N:P ratios playing a key role in determining their trajectories.
Xiaodong Sun   +8 more
wiley   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

open access: yesAdvanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei   +13 more
wiley   +1 more source

Precision‐Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart‐Warning of Weightlessness Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
It is synthesized precision‐arranged DNA origami plasmonic nanoantennas for multiplexed and intelligent warning of bone loss induced by microgravity and radiation. The ordered nanoantennas simultaneously and accurately detected calcium ions, interleukin‐6, and microRNA‐214 in serum from mice exposed to microgravity and radiation, with performance ...
Yufan Ling   +14 more
wiley   +1 more source

Controllable Generation of Pathogen‐Specific Antimicrobial Peptides Through Knowledge‐Aware Prompt Diffusion Model

open access: yesAdvanced Science, EarlyView.
KPPepGen is a knowledge‐aware prompt diffusion model for the controllable generation of pathogen‐specific AMPs. It outperforms existing methods and is capable of simultaneously generating peptides for distinct pathogens, demonstrating superior performance with favorable properties and docking efficacy.
Yongkang Wang   +4 more
wiley   +1 more source

Big Data and AI‐Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition

open access: yesAdvanced Science, EarlyView.
This review summarizes the current landscape of big data and AI‐powered modeling in animal nutrition, covering techniques including intelligent data acquisition, data augmentation, explainable machine learning, heuristic algorithms, and life cycle assessment‐based sustainability evaluation.
Shuai Zhang   +3 more
wiley   +1 more source

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