Results 251 to 260 of about 4,859,475 (319)

Leveraging Transfer Learning to Overcome Data Limitations in Czochralski Crystal Growth

open access: yesAdvanced Theory and Simulations, EarlyView.
A data‐driven framework combining Computational Fluid Dynamics (CFD) simulations and machine learning is proposed to model and optimize Czochralski crystal growth. Using different transfer learning strategies (Warm Start, Merged Training, and Hyperparameter Transfer) the study demonstrates improved predictions for Ge and GaAs growth from Si‐trained ...
Milena Petkovic   +3 more
wiley   +1 more source

Toward a Universal Czochralski Growth Model Leveraging Data‐Driven Techniques

open access: yesAdvanced Theory and Simulations, EarlyView.
This data‐driven study investigates Czochralski growth using Decision Trees, Symbolic Regression, ANN, and SHAP to assess the impact of 21 process and design parameters on crystal quality. Trained on 632 CFD simulation datasets across four crystalline materials, it demonstrates the feasibility of a universal Cz model applicable to various ...
Natasha Dropka   +4 more
wiley   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu   +15 more
wiley   +1 more source

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

open access: yesAdvanced Science, EarlyView.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian   +15 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

open access: yesAdvanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma   +10 more
wiley   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

open access: yesAdvanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro   +10 more
wiley   +1 more source

Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity

open access: yesAdvanced Science, EarlyView.
The current bottleneck in metanephric mesenchyme (MM)‐derived nephron organoid development is the absence of a connected network of collecting ducts (CD) derived from the ureteric bud (UB). To address this limitation, this study proposes a hypoxia‐based differentiation method that mimics the natural renal developmental environment, enabling the ...
Hyeonji Lim   +6 more
wiley   +1 more source

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