Advanced Science, EarlyView.A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding +5 more
wiley +1 more source
A Novel Ensemble Framework for Comprehensive Early-Stage Colorectal Cancer Diagnosis, Prognosis, and Treatment: Integration of Gastroenterology-Specific Transformer Language Models and Multiple Decision Trees. [PDF]
J Clin MedSimsek C, Ucdal M, Yalcin S, Karakoc D.
europepmc +1 more source
Decision tree model 1 (Raw error counts, performance-optimized).
Elizaveta Vasyura (22505070) +10 more
openalex +1 more source
Asynchronous Parallel Sampling Gradient Boosting Decision Tree. [PDF]
, 2018 Daning Cheng +3 more
openalex
Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes
Advanced Science, EarlyView.Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji +12 more
wiley +1 more source
Comparative Analysis of Decision Trees on Two COVID-19 Symptom Datasets
, 2023 Saengamnatdej S +2 more
europepmc +1 more source
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
Gradient boosted decision trees reveal nuances of auditory discrimination behavior. [PDF]
PLoS Comput BiolGriffiths CS +3 more
europepmc +1 more source
Gradient boosted decision trees reveal nuances of auditory discrimination behavior
, 2023 Griffiths C +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik +13 more
wiley +1 more source