Results 251 to 260 of about 4,693,052 (300)

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations

Advanced Science, EarlyView.
This study investigates bidirectional introgression between Chinese and European pig populations, revealing 3558 introgressed genomic segments and 30 structural variations. Analysis of the BMP2 region suggests its role in body size enhancement. By integrating ancient and modern genomes, the study highlights the impact of introgression on genetic ...
Yibin Qiu, Langqing Liu, Min Huang, Donglin Ruan, Rongrong Ding, Zebin Zhang, Enqin Zheng, Shiyuan Wang, Shaoxiong Deng, Xianglun Meng, Xinyan Cheng, Jiaxin Shi, Yingshan Yang, Fuchen Zhou, Sixiu Huang, Huaqiang Yang, Zicong Li, Gengyuan Cai, Zhenfang Wu, Jie Yang   +19 more
wiley   +1 more source

Anion Exchange Membrane Seawater Electrolysis at 1.0 A cm−2 With an Anode Catalyst Stable for 9000 H

Advanced Science, EarlyView.
The CAPist‐S1 catalyst containing dense interlayer structure is synthesized by one‐step autologous method. The dense NiFe LDH interlayer inhibits the Cl− ions penetration onto metal substrate, significantly improving the corrosion resistance. The obtained catalyst requires an overpotential of 220 mV at 1.0 A cm−2 and exhibits excellent durability over ...
Jian Du, Zhiheng Li, Linqin Wang, Yunxuan Ding, Wentao Ye, Wenxing Yang, Licheng Sun   +6 more
wiley   +1 more source

Highly Oriented SiC@SiO2 Ceramic Fiber Aerogels with Good Anisotropy of the Thermal Conductivity and High‐Temperature Resistance

Advanced Science, EarlyView.
The anisotropic‐structure SiC@SiO2 ceramic fiber aerogels feature aligned layers stacking layer‐by‐layer with the same direction and highly oriented 1D fibers inside each layer, resulting in an anisotropy factor as high as 5.08. Not only does it have 60% high recoverable deformation, but it also shows great promise for thermal protection in extreme ...
Zheng Zhang, Cui Liu, Nian Li, Wei Guo, Ying Li, Pengzhan Yang, Shudong Zhang, Zhenyang Wang   +7 more
wiley   +1 more source

AI‐Driven TENGs for Self‐Powered Smart Sensors and Intelligent Devices

Advanced Science, EarlyView.
Triboelectric nanogenerators (TENGs) enable sustainable energy harvesting and self‐powered sensing but face challenges in material optimization, fabrication, and stability. Integrating artificial intelligence (AI) enhances TENG performance through machine learning, improving energy output, adaptability, and predictive maintenance.
Aiswarya Baburaj, Syamini Jayadevan, Akshaya Kumar Aliyana, Naveen Kumar SK, George K Stylios   +4 more
wiley   +1 more source

Using Evolutionary Algorithms to Induce Oblique Decision Trees

, 2000
Erick Cantú‐Paz, Chandrika Kamath
openalex   +1 more source

Unveiling Salt Tolerance Mechanisms in Plants: Integrating the KANMB Machine Learning Model With Metabolomic and Transcriptomic Analysis

Advanced Science, EarlyView.
Salt stress endangers coastal cereal crops, requiring resilient crop solutions. This study employs machine learning (KANMB) to analyze multi‐omics data from halophyte Spartina alterniflora, revealing 226 salt‐stress biomarkers and linking them to tolerance pathways. The MYB gene SaMYB35 regulates flavonoid biosynthesis under salinity.
Shoukun Chen, Hao Zhang, Shuqiang Gao, Kunhui He, Tingxi Yu, Shang Gao, Jiankang Wang, Huihui Li   +7 more
wiley   +1 more source

OcuPair, a Novel Photo‐crosslinkable PAMAM Dendrimer‐Hyaluronic Acid Hydrogel Bandage/Bioadhesive for Corneal Injuries and Temporary Corneal Repair

Advanced Science, EarlyView.
A schematic diagram showing the OcuPair adhesive hydrogel formulation loaded into the final delivery device and applied over the full‐thickness corneal wound in an in vivo rabbit model of corneal injury followed by in situ crosslinking to form a transparent hydrogel bandage sealing the wound.
Siva P. Kambhampati, Rishi Sharma, Hui Lin, Santiago Appiani, Jeffrey L. Cleland, Samuel C. Yiu, Rangaramanujam M. Kannan   +6 more
wiley   +1 more source

Synergistic Machine Learning Guided Discovery of ABa3(BSe3)2X (A = Rb, Cs; X = Cl, Br, I): A Promising Family as Property‐Balanced IR Functional Materials

Advanced Science, EarlyView.
A synergistic framework for interpretable ML‐assisted target discovery of selenoborates is developed. ABa3(BSe3)2X (A = Rb, Cs; X = Cl, Br, I) are successfully predicted and synthesized, exhibiting significant potential to be promising IR functional materials. This work promotes the cooperation of ML technology and materials science.
Yihan Yun, Mengfan Wu, Zhihua Yang, Guangmao Li, Shilie Pan   +4 more
wiley   +1 more source

Explainable Deep Multilevel Attention Learning for Predicting Protein Carbonylation Sites

Advanced Science, EarlyView.
Selective carbonylation sites (SCANS) are conceptualized, designed, evaluated, and released. SCANS captures segment‐level, protein‐level, and residue embeddings features. It utilizes elaborate loss function to penalize cross‐predictions at the residue level.
Jian Zhang, Jingjing Qian, Pei Wang, Xuan Liu, Fuhao Zhang, Haiting Chai, Quan Zou   +6 more
wiley   +1 more source