Results 271 to 280 of about 5,778,654 (336)

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

Advanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie, Jiaxin Han, Xingyi Dai, Xuyang Zhang, Kangwen Xiao, Junhui Huang, Yajun Cao, Aihua Zhong, Long‐Biao Huang   +8 more
wiley   +1 more source

GBDT-IL: Incremental Learning of Gradient Boosting Decision Trees to Detect Botnets in Internet of Things. [PDF]

Sensors (Basel)
Chen R, Dai T, Zhang Y, Zhu Y, Liu X, Zhao E.   +5 more
europepmc   +1 more source

Long‐Term Active Rather than Passive Restoration Promotes Soil Organic Carbon Accumulation by Alleviating Microbial Nitrogen Limitation in an Extremely Degraded Alpine Grassland

Advanced Science, EarlyView.
Active restoration increases soil organic carbon stocks by reducing microbial nitrogen limitation. Nitrogen availability promotes particulate to mineral‐associated organic carbon conversion by reducing microbial carbon use efficiency. Passive restoration has no effect on soil organic carbon stocks.
Jinchao Gong, Feida Sun, Jingjing Wu, Shijie Zhou, Yue Xiu, Linlin Li, Tahmina Kausar, Zhouwen Ma, Jiqiong Zhou, Lin Liu, Yongxing Cui, Jordi Sardans, Josep Peñuelas, Ahmed Elrys, Ji Chen, Yanfu Bai   +15 more
wiley   +1 more source

A multi-stage machine learning framework for stepwise prediction of tuberculosis treatment outcomes: Integrating gradient boosted decision trees and feature-level analysis for clinical decision support

Wang L, Campino S, Clark TG, Phelan JE.
europepmc   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Rapid Arbitrary‐Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment

Advanced Science, EarlyView.
This study presents a novel microscopic imaging system capable of rapid, section‐free scanning of irregular tissue surfaces, delivering high sensitivity for detecting cancer cell clusters during intraoperative tumor margin assessment. Abstract Rapid and accurate intraoperative examination of tumor margins is crucial for precise surgical treatment, yet ...
Zhicheng Shao, Xiangwei Meng, Peifen Fu, Keer Huang, Xibei Chen, Yue Ying, Jun Li, Yuxin Zheng, Xiaolong Li, Hyeon Jeong Lee, Jingyi Feng, Yuexin Lu, Runping Cai, Xiongling Jiang, Qing Chen, Hong Zhang, Xiaoyong Man, Li Lin   +17 more
wiley   +1 more source

Project portfolio management on steroids: Simulating portfolio decisions using value driver trees

Carsten Feldmann, Benjamin Matthies
openalex   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source