Results 41 to 50 of about 19,228 (290)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Smart relaying for selection combining based decode-and-forward cooperative networks

, 2014
This letter proposes three smart relaying strategies, including power allocation, continuous power control, and discrete power control strategies, to mitigate the error propagation problem for single-relay decode-and-forward cooperative networks using ...
Xiang, Wei, Zhao, Dawei, Jia, Min, Zhao, Honglin   +3 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Differential space-time shift-keying aided successive-relaying-assisted decode-and-forward cooperative multiuser CDMA

, 2013
A Differential Space-Time Shift Keying (DSTSK) aided and successive relaying assisted multi-user Decode-and-Forward (DF) cooperative system is proposed. We employ low-complexity non-coherent detection, which does not require any channel state information,
Chen, Sheng, Zhang, Peichang, Hanzo, Lajos   +2 more
core   +1 more source

Maximum Euclidean distance network coded modulation for asymmetric decode-and-forward two-way relaying

, 2013
Network coding (NC) compresses two traffic flows with the aid of low-complexity algebraic operations, hence holds the potential of significantly improving both the efficiency of wireless two-way relaying, where each receiver is collocated with a ...
Chen, Wei, Hanzo, Lajos, Cao, Zhigang
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Successive-relaying-aided decode-and-forward coherent versus noncoherent cooperative multicarrier space–time shift keying

, 2013
—Successive-relaying-aided (SR) cooperative multi-carrier (MC) space–time shift keying (STSK) is proposed for frequency-selective channels. We invoke SR to mitigate the typical 50% throughput loss of conventional half-duplex relaying schemes and MC code ...
Li, Li, Chen, Sheng, Kadir, Mohammad Ismat, Hanzo, Lajos   +3 more
core   +1 more source

Power allocation and capacity optimization of multi-relay cooperative communication system in tunnel

Gong-kuang zidonghua, 2015
The multi-relay cooperative communication system model in rectangular tunnel based on multimode channel model was established, and the channel capacity calculation formulas of multi-relay cooperative communication system in amplify and forward mode and ...
ZHAI Wenyan, SUN Yanjing, LI Song, LIANG Dihui   +3 more
doaj   +1 more source