Results 91 to 100 of about 500,674 (362)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Noise Correlation-Aided Iterative Decoding for Magnetic Recording Channels

, 2006
In this paper, three noise correlation-aided iterative decoding schemes are proposed for magnetic recording channels, where the correlation is imposed by the equalizer's spectral shaping effect.
Suvit Nakpeerayuth, Lunchakorn Wuttisittikulkij, Pisit Vanichchanunt, Nakpeerayuth, S, Wuttisittikulkij, L, Kampol Woradit, Vanichchanunt, P, Woradit, K, Hanzo, L, Lajos Hanzo   +9 more
core   +1 more source

Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements

eLife, 2018
The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat’s position can be decoded with high spatiotemporal resolution from ACC activity.
Ali Mashhoori, Saeedeh Hashemnia, Bruce L McNaughton, David R Euston, Aaron J Gruber   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Efficient Context-Preserving Encoding and Decoding of Compositional Structures Using Sparse Binary Representations

Information
Despite their unprecedented success, artificial neural networks suffer extreme opacity and weakness in learning general knowledge from limited experience.
Roman Malits, Avi Mendelson
doaj   +1 more source

DIFFERENTIATION OF POLYNOMIALS IN SEVERAL VARIABLES OVER GALOIS FIELDS OF FUZZY CARDINALITY AND APPLICATIONS TO REED-MULLER CODES

Advanced Engineering Research, 2018
Introduction. Polynomials in several variables over Galois fields provide the basis for the Reed-Muller coding theory, and are also used  in a number of cryptographic problems.
V. M. Deundyak, N. S. Mogilevskaya
doaj   +1 more source

Reading and Decoding the Persian Language Satellite Channels’ Procedure The Case Study of Tehranian Youth Reading Persian Language Pastime and Political Satellite Channels [PDF]

Taḥqīqāt-i Farhangī-i Īrān, 2014
Thisstudyseeks toanswer to thisfundamental questionwhich howyoungaudiences of specific Persian languagesatellitechannels are engagedinreadingthe communicative messagesfromsuch channels and what kind of messages of such channels’ reading they do?
Mahdi Montazerghaem, Reza Kavand
doaj   +1 more source

Decoding the decoder: Contextual sequence-to-sequence modeling for intracortical speech decoding

CoRR
Speech brain--computer interfaces require decoders that translate intracortical activity into linguistic output while remaining robust to limited data and day-to-day variability. While prior high-performing systems have largely relied on framewise phoneme decoding combined with downstream language models, it remains unclear what contextual sequence-to ...
Michal Olak, Tommaso Boccato, Matteo Ferrante   +2 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source