Results 271 to 280 of about 500,674 (362)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Independence and coherence in temporal sequence computation across the fronto-parietal network. [PDF]

Nat Commun
Imamura H, Imamura F, Hira R, Isomura Y, Hira R.   +4 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Pain expression and decoding as intergroup phenomena. [PDF]

Affect Sci
Summers KM, Lloyd EP.
europepmc   +1 more source

Study of Free‐Space Optical Quantum Network: Review and Prospectives

Advanced Science, EarlyView.
Free from the constraints of fiber connections, free‐space quantum network enables longer and more flexible quantum network connections. This review summarizes and comparatively analyzes free‐space quantum network experiments based on ground stations, satellites, and mobile platforms.
Hua‐Ying Liu, Zhenda Xie, Shining Zhu
wiley   +1 more source

Decoding real-world visual scenes from alpha and gamma band flicker evoked oscillations in human EEG. [PDF]

Sci Rep
Dowsett J, Muñoz IM, Taylor P.
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Recognition of the wobble pair: quantum mechanical calculations of tRNA U34 or C34 modifications within the ribosomal decoding center. [PDF]

Nucleic Acids Res
Liu Y, Zeng S, Yang Z, Chen S, Liu M, Zhu D, Wang M, Jia R, Cheng A, Westhof E, Ou X.   +10 more
europepmc   +1 more source

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Decoding correlated errors in quantum LDPC codes. [PDF]

Nat Commun
Maan AS, Garcia Herrero FM, Paler A, Savin V.   +3 more
europepmc   +1 more source