Results 151 to 160 of about 60,061 (259)

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping. [PDF]

Elife
Grier HA, Salimian S, Kaufman MT.
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Near-Optimal Decoding Algorithm for Color Codes Using Population Annealing. [PDF]

Entropy (Basel)
Martínez-García F, F Pereira FR, Parrado-Rodríguez P.   +2 more
europepmc   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

The Tool for Automatic Analysis of Decoding Ambiguity (TAADA). [PDF]

Behav Res Methods
Crossley S, Choi JS, Tang K, Cutting L.
europepmc   +1 more source

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

Advanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin, Mehdi Liauzun, Jacobo Solorzano, Morgane Le Bras, Christine Jean, Benjamin Fourneaux, Margaux Dore, Lea Fevrier, Ismahane Belhabib, Alexia Brunel, Cindy Neuzillet, Marion Larroque, Carine Joffre, Stephane Rocchi, Nicolas Fraunhoffer, Aurelie Perraud, Muriel Mathonnet, Vera Pancaldi, Laetitia Linares, Juan Iovanna, Nelson Dusetti, Ola Larsson, Remy Nicolle, Stephane Pyronnet, Corinne Bousquet, Yvan Martineau   +25 more
wiley   +1 more source

Optimal hyperdimensional representation for learning and cognitive computation. [PDF]

Front Artif Intell
Poduval PP, Errahmouni Barkam H, Liu X, Yun S, Ni Y, Zou Z, Bastian ND, Imani M.   +7 more
europepmc   +1 more source

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

Advanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet, Priyanka Kumari, Sathyanarayana Paladugu, Damian Pociecha, Jakub Karcz, Przemysław Kula, Nataša Vaupotič, Ewa Górecka, Oleg D Lavrentovich   +8 more
wiley   +1 more source