Results 31 to 40 of about 305,011 (265)
Water Resources Research, 2023 Due to the uncertainty in sensor data, low model accuracy, and high parameter heterogeneity in water quality modeling, pollution source detection (PSD) typically results in a problem of multiple possible solutions, which is the so‐called non‐uniqueness ...
Zhe Zhu +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Energy Optimization Analysis of Turbofan Engine for More-Electric Civil Aircraft
IEEE Access, 2020 The civil aviation industry is moving into the more-electric environment where the civil aircraft uses electricity to meet the multiple energy demands of the associated aircraft subsystems.
Yuanchao Yang, Hao Li, Chen Yu
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Image decomposition method by topological features
Компьютерная оптика, 2022 A new method for decomposing an image into separate objects of interest is proposed in the article. The developed method is based on the use of persistent homology. A process of direct and reverse image transformation is shown.
S.V. Eremeev +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Вісник Національного технічного університету "ХПÌ": Системний аналіз, управління та інформаційні технологіїThe authors created a universal method of constructing multivariate polynomial regression given by a redundant representation. The method is synthetic, it organically combines a decomposition method and the modified group method of data handling.
Alexander Pavlov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source