Results 71 to 80 of about 107,812 (293)
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, EarlyView.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
World Neurosurgery: XBackground: Lumbar decompression is a commonly performed procedure for the operative management of several degenerative lumbar spinal pathologies.
Confidence K. Kpegeol +5 more
doaj +1 more source
Acta Orthopaedica et Traumatologica Turcica, 2018 Introduction: The aim of this study is to evaluate whether early (
Dong-Yeong Lee +5 more
doaj +1 more source
Evaluation of a pig femoral head osteonecrosis model [PDF]
, 2010 Background A major cause of osteonecrosis of the femoral head is interruption of a blood supply to the proximal femur. In order to evaluate blood circulation and pathogenetic alterations, a pig femoral head osteonecrosis model was examined to address ...
Kim, Harry +3 more
core +2 more sources
Advanced Science, EarlyView.KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen +19 more
wiley +1 more source
Diffusion Tensor Imaging in a Large Longitudinal Series of Patients With Cervical Spondylotic Myelopathy Correlated With Long-Term Functional Outcome [PDF]
, 2018 BACKGROUND Fractional anisotropy (FA) of the high cervical cord correlates with upper limb function in acute cervical cord injury. We investigated the correlation between preoperative FA at the level of maximal compression and functional recovery in a ...
Budde, Matthew D. +8 more
core +1 more source
Advanced Science, EarlyView.This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang +15 more
wiley +1 more source
Managing the Complex Patient with Degenerative Cervical Myelopathy: How to Handle the Aging Spine, the Obese Patient, and Individuals with Medical Comorbidities. [PDF]
, 2018 Degenerative cervical myelopathy (DCM) is the most common cause of nontraumatic spinal cord injury worldwide. Even relatively mild impairment in functional scores can significantly impact daily activities.
Gillick, John +3 more
core +1 more source
Nonobstructing Colonic Dilatation and Colon Perforations Following Renal Transplantation [PDF]
, 1990 Nonobstructing colonic dilatation has not been commonly reported following renal transplantation, and colon perforations carry a high morbidity and mortality in this population.
Hakala, TR +5 more
core +1 more source
Chemically Driven Nano‐Elastic Heterogeneities Control Fragility in Volcanic Melts
Advanced Science, EarlyView.The study elucidates how nanoscale structural heterogeneity governs the mechanical behavior of volcanic glasses across compositions from basalt to rhyolite. Using a physicochemical framework, correlation length (ξ) and microscopic free volume (Vc) are derived from vibrational and physical properties, revealing systematic trends with silica content that
Michele Cassetta +13 more
wiley +1 more source