Correction: Improving tractography in peri-lesional oedema using constrained spherical deconvolution in paediatric neurosurgery patients. [PDF]
Brain Struct FunctYang JY +3 more
europepmc +1 more source
Advanced Science, EarlyView.An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu +8 more
wiley +1 more source
STEA: Histologically Validated and Reference-Independent Major Cell-Type Annotation for Spatial Transcriptomics Reveals Relevant Cellular Organization and Architecture of Tumor Microenvironment. [PDF]
Cancers (Basel)Li Q, Zhang Q, Zeng F, Ng IO, Ho DW.
europepmc +1 more source
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti +15 more
wiley +1 more source
SA2E: spatial-aware auto-encoder for cell type deconvolution of spatial transcriptomics data. [PDF]
BioinformaticsMa Y, Dou Z, Zha Y, Ma X.
europepmc +1 more source
Defect‐Functionalization‐Mediated Tunneling Drives Nonlinear Photoemission in Perovskites
Advanced Science, EarlyView.This cover illustration depicts CsPbBr3 perovskite nanocrystals embedded with functionalized defect vacancies, where electrons migrate through defect‐mediated pathways and emit as lightning‐like beams. The imagery visualizes the core discovery of our work—defect‐functionalization‐mediated tunneling enabling nonlinear photoemission, where deep‐level ...
Hang Ren +9 more
wiley +1 more source
CSsingle: a unified tool for robust decomposition of bulk and spatial transcriptomic data across diverse single-cell references. [PDF]
Nucleic Acids ResShen W +6 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi +13 more
wiley +1 more source
Evaluation of the use of segmentation-based and deconvolution-based three-dimensional joint space width analysis of the hand and wrist. [PDF]
JBMR PlusQuintiens J +4 more
europepmc +1 more source
Advanced Science, EarlyView.The crystalline structure, the atomic numbers of the constituent elementsand the size of MOF crystals each influence their photoluminescence and scintillation properties in distinct ways. Together, these factors provide valuable guidelines for designing systems with optimized performance and tunable timing characteristics, arising from the synergistic ...
Francesca Cova +8 more
wiley +1 more source