Results 201 to 210 of about 241,357 (270)

Integrative spatial multi-omics reveal niche-specific inflammatory signaling and differentiation hierarchies in AML. [PDF]

iScience
Dasdemir E, Veletic I, Ly CP, Quesada AE, Pacheco CD, Jelloul FZ, Borges P, Basu S, Jindal S, Wang Z, Lazar A, Wani KM, Antunes DA, Reville PK, Gunaratne PH, Tower RJ, Sharma P, Abbas HA.   +17 more
europepmc   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Ill-posed analysis of time-domain deconvolution identification of ice load on the shell structures of ice-going vessels. [PDF]

Sci Rep
Kong S, Lei J.
europepmc   +1 more source

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Molecular and cellular composition changes after neoadjuvant letrozole and palbociclib in early luminal breast cancer. [PDF]

Cell Rep Med
Cottu P, Kieffer Y, Lemonnier J, D'hondt V, Duhoux FP, Callens C, Gentien D, Reyes C, Boulai A, Desmoulins I, Mouret-Reynier MA, Levy C, Heudel PE, Dalenc F, Grenier J, Fuhrmann L, Baulande S, Delaloge S, Mechta-Grigoriou F, Vincent-Salomon A.   +19 more
europepmc   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

A benchmark of DNA methylation deconvolution methods for tumoral fraction estimation using DecoNFlow

Giuili E, Van de Velde S, Kint S, Ferro dos Santos MR, Cornelli L, Roelandt S, Schoofs K, Imschoot R, Van Paemel R, Meuris L, Everaert C, De Preter K.   +11 more
europepmc   +1 more source

From pixels to cell types: a comprehensive review of computational methods for spatial transcriptomics deconvolution. [PDF]

Genomics Inform
Saqib J, Kim J.
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Unico: a unified model for cell-type resolution genomics from heterogeneous omics data. [PDF]

Genome Biol
Chen ZJ, Rahmani E, Halperin E.
europepmc   +1 more source