Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
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FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
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THE PRESIDENT OF ROMANIA: DESIGNATION, ROLE, MANDATE [PDF]
Annals of the University of Petrosani: EconomicsThe President of Romania is elected through universal, equal, direct, secret, and freely expressed vote. In order to run for this office, the individual must be a Romanian citizen and at least 35 years of age.
ADELIN UNGUREANU
doaj
The Acts and Decrees of the Synod of Jerusalem, Sometimes Called the Council of Bethlehem, Holden under Dasetheus, Patriarch of Jerusalem, 1672. J. N. W. B. Robertson [PDF]
, 1900 J. W. Moncrief
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, 2013 This paper examines the degree to which public participation in concession-based forestry decision-making - as outlined by the Environmental Impact Assessment (EIA) Decree (No.
D. Alemagi +3 more
semanticscholar +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
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TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
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Revista Principia, 2019 The decade of 1990 was the scene ofsignificant transformations in the economic, social and educational realms. Regarding education, especially Vocational and Technological Education, the Decree number 2,208/1997, signed by the former President Fernando ...
Ana Paula Marinho de Lima +2 more
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The Committee for Internal Control and Legal Audit Introduced by Art.10 of the Legislative Decree Nr.39/2010 in Italy: Remarks on a Stage of Its First Setting up in Compliance with EU Guidelines [PDF]
, 2015 Claudio Sottoriva
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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
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