Results 71 to 80 of about 528,479 (388)

LEGALITAS PERIZINAN LINGKUNGAN :(Studi Kasus PT Semen Indonesia berdasarkan Surat Keputusan Gubernur Jawa Tengah Nomor 606.1/4 Tahun 2017) [PDF]

open access: yes, 2018
Implementation of Environmental Permit for PT. The Indonesian cement in Rembang, Central Java based on the Governor Decree 660.1 / 6 2017 did not work as it should. Kendeng Mountain Community who refused the presence of PT.
Latif, Muhamad
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

REGULARYFRAMWORK AND LEGAL BASE OF ELECTRONIC DOCUMENT CIRCULATION

open access: yesІнформаційні технології і засоби навчання, 2010
The general characteristic of legal base of electronic document circulation is presented in the article. It legislatively regulates the relations which connected with the information and information communication technologies. There is presented the list
Taisiia H. Omelchenko   +1 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The Italian national law on forests and forest supply chains: the landscape, the goods (and the woodlands), and the interventions to be set

open access: yesForest@, 2020
One of the implementing decrees of the Italian national forest law no. 34 of 2018 deals with the interventions to be set in the woodlands protected by the art. 136 of the national landscape and cultural heritage code (legislative decree no.
Sitzia T
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

THE TRANSFORMATION PHENOMENON IN THE HOLIDAY CULTURE OF PEASANTS FROM THE EUROPEAN NORTH OF RUSSIA IN 1911 – THE FIRST HALF OF THE 1930s (BASED ON PEASANT DIARIES)

open access: yesИзвестия высших учебных заведений. Поволжский регион: Гуманитарные науки, 2020
Background. The first third of the XX century in the history of our country is characterized by global changes in all spheres of society. They were associated with a change in the political system.
V. S. Zhukova
doaj   +1 more source

Speech Patterns in Litigation Documents (Exemplified by Decrees)

open access: yesVestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 2. Âzykoznanie, 2020
he study focuses on speech patterns typically used in litigation documents issued at the stage of criminal proceeding initiation and pre-trial investigation, which belong to the genre of decree.
Yuliia V. Donskova
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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