Results 131 to 140 of about 87,998 (303)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen   +13 more
wiley   +1 more source

علاقة التعليل والمصالح في مقاصد الحكم التكليفي

open access: yesBartın Üniversitesi İslami İlimler Fakültesi Dergisi, 2017
تناول هذا البحث العلاقة بين التعليل والمصالح ومقاصد الحكم، فان احكام الله تعالى معللة. فهذا التعليل مرتبط بالمصلحة التي يبتغي ان يوصلها الشرع للمكلفين. فبثبوت التعليل تثبت المصلحة التي عن طريقهما تثبت المقاصد في الاحكام التكليفية.
Badran Thaeer Abdulqader Qumrı
doaj  

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

open access: yesAdvanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai   +9 more
wiley   +1 more source

Anisotropic Memristive Switching in NbOCl2 Enabled by Directional Oxygen Ion Migration

open access: yesAdvanced Science, EarlyView.
This study investigates strongly orientation‐dependent memristive switching in anisotropic NbOCl2, observed exclusively along the in‐plane c‐axis. The switching originates from direction‐selective oxygen‐ion migration and vacancy propagation that modulate the Pd/NbOCl2 Schottky barrier, enabling short‐term plasticity.
Caokun Wang   +6 more
wiley   +1 more source

Tackling ”until induction” in natural deduction for PLTL

open access: yes, 2008
We investigate the problem of induction in the natural deduction construction of propositional linear-time temporal logic. The well known induction with the “always in the future” operator has been an obstacle in our previous developments of the proof ...
Bolotov, A.
core  

A Simpler formulation of natural deduction calculus for linear-time temporal logic [PDF]

open access: yes, 2007
The paper continues our studies of natural deduction calculus for the propositional linear-time temporal logic PLTL. We present a new formulation of natural deduction calculus for PLTL. The system is shown to be sound and complete.
Bolotov, A., Grigoriev, O., Shangin, V.
core  

Promoting Electroreduction CO2 to Multi‐Carbon Products by Tailoring the *H Availability With Optimized Interfacial H2O Configuration

open access: yesAdvanced Science, EarlyView.
A catalysis system with adjustable interfacial H2O configuration was conducted by introducing ionomer into Cu. The increasing proportion of K+‐H2O can enhance the dissociation of H2O and improve the generation ability of *H, and the increasing proportion of 4‐HB‐H2O can accelerate the transfer speed of *H to *CO intermediates with the aid of strong ...
Dawei Zhou   +5 more
wiley   +1 more source

StackingNet: Collective Inference Across Independent AI Foundation Models

open access: yesAdvanced Science, EarlyView.
ABSTRACT Artificial intelligence (AI) built on large foundation models has transformed language understanding, computer vision, and reasoning, yet these systems remain isolated and cannot readily share their capabilities. Coordinating the complementary strengths of independently developed, black‐box foundation models is essential for trustworthy ...
Siyang Li   +4 more
wiley   +1 more source

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