Results 41 to 50 of about 29,327 (261)

How to deduplicate PCR [PDF]

Nature Methods, 2017
PCR duplicates—sequencing reads from the same original genomic fragment—can cause headaches. But there are remedies.
openaire   +2 more sources

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Deduplication-Aware Healthcare Data Distribution in IoMT

Mathematics
As medical sensors undergo expeditious advancements, there is rising interest in the realm of healthcare applications within the Internet of Medical Things (IoMT) because of its broad applicability in monitoring the health of patients.
Saleh M. Altowaijri
doaj   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Implications of deduplication on the detection rates of multidrug-resistant organism (MDRO) in various specimens: insights from the hospital infection surveillance program

Antimicrobial Resistance and Infection Control
Background Currently, different guidelines recommend using different methods to determine whether deduplication is necessary when determining the detection rates of multidrug-resistant organisms (MDROs).
Zhanjie Li, Dan Zhu, Xiaoju Ma, Feng Zang, Weihong Zhang, Can Luo, Chuanlong Zhu, Wensen Chen, Ping Zhu   +8 more
doaj   +1 more source

Mega, Digital Storage Lockers, and the DMCA: Will Innovation Be Stifled by Fears of Piracy? [PDF]

, 2014
Kim Dotcom, founder of Megaupload Limited, has been in many news headlines over the past year. Megaupload—one of Dotcom’s many peer-to-peer sharing sites—was the center of controversy, as it allowed users to upload and share all sorts of files, including
Mirsaidi, Ali V
core   +1 more source

Large Language Model in Materials Science: Roles, Challenges, and Strategic Outlook

Advanced Intelligent Discovery, EarlyView.
Large language models (LLMs) are reshaping materials science. Acting as Oracle, Surrogate, Quant, and Arbiter, they now extract knowledge, predict properties, gauge risk, and steer decisions within a traceable loop. Overcoming data heterogeneity, hallucinations, and poor interpretability demands domain‐adapted models, cross‐modal data standards, and ...
Jinglan Zhang, Xinyi Chen, Xu Ye, Yulin Yang, Bin Ai   +4 more
wiley   +1 more source

Indeterministic Handling of Uncertain Decisions in Duplicate Detection [PDF]

, 2010
In current research, duplicate detection is usually considered as a deterministic approach in which tuples are either declared as duplicates or not. However, most often it is not completely clear whether two tuples represent the same real-world entity or
Keulen, Maurice van, Panse, Fabian, Ritter, Norbert   +2 more
core   +2 more sources

ERBlox: Combining Matching Dependencies with Machine Learning for Entity Resolution

, 2017
Entity resolution (ER), an important and common data cleaning problem, is about detecting data duplicate representations for the same external entities, and merging them into single representations. Relatively recently, declarative rules called "matching
Bahmani, Zeinab, Bertossi, Leopoldo, Vasiloglou, Nikolaos   +2 more
core   +1 more source