Results 111 to 120 of about 514,183 (307)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Supporting active cognitive processing in collaborative groups: the potential of Bloom's taxonomy as a labeling tool [PDF]
, 2009 De Wever, Bram +3 more
core +2 more sources
Kebijakan Pertanggungjawaban Pidana Notaris Sehubungan dengan Kedudukannya sebagai Pejabat Pembuat Akta [PDF]
, 2012 In UUJN doesn\u27t regulate peculiarly hit criminal rule, only regulate rule hits stoppage and sanction towards notary public, that is in section 12, section 13, and paragraph 84 because contractual terms that between notary public with the parties stay
Eko Soponyono, Purwoto, Edi Purnomo
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Yurisdiksi: Jurnal Wacana Hukum dan Sains, 2019 Everyone needs evidence to prove the existence of a right or event, especially written evidence in the form of an authentic deed. Authentic deed is a deed in the form determined by law, made by or in front of the general employee in charge where the deed
Elok Nadhiro
doaj
Analisis Yuridis Atas Pertanggung Jawaban Notaris Terhadap Akta Fidusia Yang Dibuat Setelah Terbit Permenkumham Nomor 9 Tahun 2013 Tentang Pendaftaran Fidusia Elektronik [PDF]
, 2015 A Notary is a public official who has the authority to draw up authentic deeds and other authorities under this law. He also has the authority under Law No. 30/2004 in conjunction with Notarial Act No. 2/2014 and Law No.
SOENARYO, C. (CIPTO)
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source