Results 181 to 190 of about 514,183 (307)

Machine learning models for predicting treatment outcomes in chronic non-specific back pain patients undergoing lumbar extension traction. [PDF]

Sci Rep
Moustafa IM, Ozsahin DU, Mustapha MT, Zadeh S, Khowailed I, Oakley PA, Harrison DE.   +6 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Functionalization of Two-Component Gelatinous Peptide/Reactive Oligomer Hydrogels with Small Molecular Amines for Enhanced Cellular Interaction. [PDF]

Int J Mol Sci
Kohn-Polster C, Müller BM, Krieghoff J, Nawaz A, Maqsood I, Starke A, Haastert-Talini K, Schulz-Siegmund M, Hacker MC.   +8 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Metagenomic complexity of high, seasonal transmission of Plasmodium spp. in asymptomatic carriers in Northern Sahelian Ghana. [PDF]

Commun Med (Lond)
Tan MH, Bangre O, Rios-Teran CA, Tiedje KE, Deed SL, Zhan Q, Rasyidi F, Pascual M, Ansah PO, Day KP.   +9 more
europepmc   +1 more source

A cost utility analysis of the clinical algorithm for nasogastric tube placement confirmation in adult hospital patients [PDF]

, 2017
Black, Brazier, Briggs, Burns, Coyle, Crocker, de Aguilar-Nascimento, Dickson, Dolan, Durai, Easterbrook, Ellet, Ellet, Eveleigh, Ghahremani, Great Britain Parliament, Husereau, ISD Scotland, Itkin, Kearns, Krenitsky, Laska, Lo, Metheny, Metheny, Metheny, Metheny, Miller, National Institute for Clinical Excellence, National Patient Safety Agency, National Patient Safety Agency, National Patient Safety Agency, Neumann, Pandey, Patrick, Philips, Rollins, Silk, Sorokin, Sparks, Stroud, The EuroQol Group, The Nordic Cochrane Centre, The Cochrane Collaboration, Ubel, Welch, Zamora   +45 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Correction to "Prevalence, Antimicrobial Resistance, and Staphylococcal Toxin Genes of Bla_TEM-1a-producing Staphylococcus aureus Isolated From Animals in Chongqing, China". [PDF]

Vet Med Sci
europepmc   +1 more source

Patient selection, clinical outcomes, associated healthcare utilization, and cost-effectiveness of basivertebral nerve ablation for the treatment of vertebrogenic low back pain: A narrative review. [PDF]

N Am Spine Soc J
Ehsanian R, Buttner JA, Schneider B, McCormick ZL.   +3 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source