Results 111 to 120 of about 4,080,830 (296)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Distribution of δ13C and δ15N of deep-sea crabs and invertebrates on the Hupo Bank of East Sea (Sea of Japan)

open access: yes, 2018
A combination of stable isotopic measurements was used to study food web structure of Hupo Bank in East Sea (Sea of Japan), an important snow crab fishing ground.
민원기   +4 more
core  

Check List of Deep Sea Fishes [PDF]

open access: yes, 2007
Under the ASEAN-SEAFDEC program on the Deep Sea Fisheries Resources Exploration in the Southeast Asian Waters has been implemented since 2007. The main objectives are to support member countries for better understanding on the existing deep sea fisheries
Prommas, Ritthirong   +2 more
core  

Body force-based method for determining flow velocity of sea water artesian circulating system

open access: yesZhongguo Jianchuan Yanjiu, 2019
[Objectives]Establish a method capable of quickly calculating the flow velocity of an artesian circulating system,in order to optimize and compare multiple design schemes for key components of the sea water artesian circulating system.[Methods]Numerical ...
Chen Kang   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Characterization of deep-sea macrobenthos in the Korea exploration claim area in the Clarion-Clipperton Fracture Zone, Northeastern Pacific

open access: yes, 2018
Macrobenthos in the Clarion-Clipperton Fracture Zone remains poorly understood, due both to gross undersampling and to the fact that most species collected from the area are new to science.
김경홍   +4 more
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Diversity of meiofauna at deep-sea hydrothermal vents and cold seeps with particular reference to nematodes

open access: yes, 2007
Deep-sea hydrothermal vents and cold seeps are remarkable for their spectacular megaandmacrofauna, many of which appear to have a high level of endemism to these chemosyntheticenvironments.
Flint, Hannah Christina
core   +1 more source

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