Results 101 to 110 of about 14,363,927 (258)
Novel Dual-Constraint-Based Semi-Supervised Deep Clustering Approach
SensorsSemi-supervised clustering can be viewed as a clustering paradigm that exploits both labeled and unlabeled data to steer learning accurate data clusters and avoid local minimum solutions.
Mona Suliman AlZuhair +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Deep PeNSieve: A deep learning framework based on the posit number system
, 2020 This paper has been supported by the Community of Madrid under grant S2018/TCS-4423, the EU (FEDER) and the Spanish MINECO under grant RTI2018-093684-B-I00 and by Banco Santander under grant PR26/16-20B-1. The source code of the proposed framework, Deep
Botella Juan, Guillermo +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Unraveling Deep-Ocean Connections to Climate with Deep-Sea Coral Records of Radiocarbon and Cd/Ca [PDF]
, 2006 We generated records of radiocarbon and trace metals in deep-sea corals to investigate the role of the deep ocean during episodes of rapid environmental change.
Eltgroth, Selene Farrell
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Jurnal PaedagogyThis study analyzes the comparative effectiveness of the GASING (Easy, Engaging, and Enjoyable) approach and the Deep Learning approach in improving the mathematics learning outcomes of elementary school students regarding whole number content.
Yudi Braja Putra, Sardin, Al Jupri
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Deep-deep neural network language models.
, 2018 Deep-deep neural network language models.
Sylvester Olubolu Orimaye (5942264) +2 more
core +1 more source