Results 121 to 130 of about 2,777,952 (193)

Reduced vessel density in deep capillary plexus correlates with retinal layer thickness in choroideremia. [PDF]

Br J Ophthalmol, 2021
Arrigo A, Romano F, Parodi MB, Charbel Issa P, Birtel J, Bandello F, Maclaren RE.   +6 more
europepmc   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Parafoveal VD box-plots of the retinal vascular plexuses in the two groups.

, 2019
Healthy subjects: blank box-plots; diabetic retinopathy (DR) patients: box-plots with vertical stripes. VD (%) is represented on the y axis. Superficial vascular plexus (SVP), deep vascular complex (DVC), intermediate capillary plexus (ICP) and deep ...
Ali Erginay (6996761), Carlo Lavia (4398148), Ramin Tadayoni (192774), Alain Gaudric (192770), Bénédicte Dupas (6996764), Aude Couturier (6996758)   +5 more
core   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Deep-UV-LEDs in photometric detection: A 255 nm LED on-capillary detector in capillary electrophoresis

, 2009
A 255 nm deep-UV-light-emitting diode (deep-UV-LED) is investigated as a novel light source for photometric detection in view of fundamental properties of UV-LEDs, in particular emission spectra and energy conversion.
Hauser, PC (15508910), Krcmova, L (15542858), Stjernlof, A (15542861), Mehlen, S (15542864), Abele, S (15522578), Brett Paull (14746423), Miroslav Macka (14743039)   +6 more
core  

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

The Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo, José M. Murrieta‐Coxca, Christian Schmeer, Lingyu Wei, Frank Steiniger, Tanja Groten, Udo R. Markert, Diana M. Morales‐Prieto   +7 more
wiley   +1 more source

Identification of TREK channels in mouse intracardiac ganglion neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Role of TWIK‐related K+ (TREK) channels in intracardiac ganglion neurons. CD‐1 mice were used to establish primary cultures of intracardiac neurons for immunochemical characterization and patch‐clamp electrophysiology. Intracardiac neurons express functional TREK channels, which modulate neuronal excitability by regulating ...
Ana Campos‐Rios, Salvador Herrera‐Perez, Manuela Rodriguez‐Castañeda, Diego Ameal‐Tedin, Marta Alvarez‐Rodriguez, David Blanco‐Remesar, Ainhoa Rodriguez‐Tebar, Encarnación De Miguel, Ana Covelo, J. Antonio Lamas   +9 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe, Michael Apollinaro, Joanna Reeves, Christopher Nester, Leah R. Bent   +4 more
wiley   +1 more source