Results 111 to 120 of about 5,335 (255)

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Generation and Enhancement of Persistent Nanoscale Magnetization in All‐Dielectric Metasurfaces by Optically Injected and Localized Free Carriers

Advanced Science, EarlyView.
Infrared metasurface‐guided waves (IR‐MGW) scattered by a time interface (TI) induced by rapid, localized free‐carrier generation can be efficiently rectified to generate strong, persistent magnetic fields. We develop a rigorous, theoretical model to study a time‐varying, dispersive medium and uncover the redistribution of the initial energy of the IR ...
Shivaksh Rawat, Samyobrata Mukherjee, Gennady Shvets   +2 more
wiley   +1 more source

Rejuvenation behavior of Cu–Zr metallic glass under different holding times during deep cryogenic cycling treatment: Experiments and simulation

Journal of Materials Research and Technology
The rejuvenation behavior of Cu–Zr binary metallic glasses with different holding times in both ambient and cryogenic temperatures during deep cryogenic cycling treatment were investigated in details.
Mingzi Wang, Shulin Lü, Shusen Wu, Jincheng Wang, Wei Guo   +4 more
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Effect of cryotreatment on the microstructural evolution of TiAlNiCrCo and TiAlNiCrFe high entropy alloy with nano TiC precipitates

Results in Surfaces and Interfaces
Cryogenic treatment is imperative for improving the microstructure and mechanical properties of high-entropy alloys (HEAs). This study examines the impact of Deep Cryogenic Treatment (DCT) on the microstructural development of TiAlNiCrFe and TiAlNiCrCo ...
S Muhammed Muneer, R Anand Sekhar, B.S Arun, N.S Faizal, Arjun Santhosh   +4 more
doaj   +1 more source

Effects of deep cryogenic treatment on the microstructure and properties of H13 steel

Journal of Physics: Conference Series
Abstract As the advanced equipment manufacturing industry progresses rapidly, mold materials have become an essential part of modern industrial applications. Among these materials, AISI H13 steel is highly valued due to its outstanding hardenability, strength, toughness, and resistance to thermal fatigue. These qualities make H13 steel a
Bowen Jiang, Jixiang Gao, Zhengwu Peng
openaire   +1 more source

Interfacial Water Configurations: Evolution and Implications for Electrocatalysis

Advanced Science, EarlyView.
A comprehensive and mechanistic understanding of how interfacial water structures govern reaction pathways. This review aims to bridge the gap between unraveling the intricate role of water structures and establishing robust design principles for advanced catalysts.
Aoqi Wang, Yang Song, Lin Guo, Chenchen Weng, Yanxia Yuan, Chaoyu Li, Xue Yang, Wei Lin   +7 more
wiley   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Nanoparticle‐Mediated Bubble Suppression During Droplet Solidification for Mechanical Reinforcement

Advanced Science, EarlyView.
Nanoparticles mediate droplet solidification by raising nucleation temperature, refining dendrites, and slowing freezing‐front advance, thereby suppressing trapped air bubbles in droplet‐based 3D printing. This strategy reduces bubble volume fraction by ∼35% and increases compressive strength by up to 39%, offering a low‐cost route to stronger printed ...
Runmiao Gao, Xuan Zhang, Mengjie Song, Ronggui Yang, Keke Shao, Jun Shen, Long Zhang, Shuhuai Yao, Yubing Guo, Ruzhu Wang, Christopher Yu Hang Chao   +10 more
wiley   +1 more source