Results 221 to 230 of about 305,244 (339)

Navigating the Flames: Comparative Analysis of Cremation Practices in the Roman and Early Medieval Periods at Gbely‐Kojatín (SK) and Přítluky (CZ)

open access: yesArchaeometry, EarlyView.
ABSTRACT Cremation became the dominant funerary practice in the Middle Danube Region during the Roman Period (RP) (1st–4th century) and reappeared in the Early Medieval Ages (EMA) (6th/7th–8th century). This study aims to reconstruct differences in cremation conditions from the Gbely‐Kojatín site (Slovakia, RP and EMA) and the Přítluky site (Czech ...
Katarína Hladíková   +4 more
wiley   +1 more source

Palaeowinds and depositional conditions from Holocene loess in Sweden and Finland

open access: yesBoreas, EarlyView.
The nature of deglacial and Holocene wind regimes in Fennoscandia is debated, as is the degree to which wind‐blown loess deposits exist in the region. Loess deposits in Fennoscandia are often relatively thin, discontinuous and less well‐sorted than typical loess, and questions remain over the degree of their post‐depositional reworking and the impact ...
Calum J. Edward   +6 more
wiley   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim   +10 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki   +4 more
wiley   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

open access: yesThe FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson   +5 more
wiley   +1 more source

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