Results 141 to 150 of about 574,508 (305)

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

open access: yesAdvanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang   +5 more
wiley   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

open access: yesAdvanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz   +10 more
wiley   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

open access: yesAdvanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang   +21 more
wiley   +1 more source

Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47

open access: yesAdvanced Science, EarlyView.
Dimethylsulfoniopropionate (DMSP) is a major marine organosulfur compound central to climate‐relevant dimethyl sulfide (DMS) production. In Halomonas sp. D47, DMSP catabolism is revealed to be coordinated by two transcriptional regulators, AcuR and AcuZ, which control gene expression by sensing DMSP and its metabolites.
Li‐Yuan Zheng   +16 more
wiley   +1 more source

Water‐Efficient Smart Drip Irrigation Enabled by a Low‐Power and High‐Efficiency Flexible Electromagnetic Actuator

open access: yesAdvanced Science, EarlyView.
Water scarcity poses a critical threat to global food security. A low‐power, flexible electromagnetic actuator is presented for smart drip irrigation systems. The device achieves precise, wide‐range flow modulation (0.05–5.8 mL/min) in response to real‐time plant demands, reducing water consumption compared to conventional flood irrigation.
Duo Chen   +7 more
wiley   +1 more source

Bio‐Based Wax Interfaces for Droplet Energy Harvesting at Fluoropolymer‐Like Output Levels

open access: yesAdvanced Science, EarlyView.
Replacing unsustainable fluorinated polymers in droplet‐based energy harvesters is usually limited by low power outputs, but carefully selected bio‐based polymers are capable of creating fluoropolymer‐like voltage outputs. Abstract Droplet impact and rebound on solid surfaces has emerged as a promising method for energy harvesting, typically ...
Behnam Kamare   +4 more
wiley   +1 more source

Compartmentalized Homeostasis Drives High Bamboo Forest Productivity under Nutrient Imbalance

open access: yesAdvanced Science, EarlyView.
This study reveals how Moso bamboo achieves high productivity despite nutrient‐poor soils. It employs a unique strategy, maintaining strict nutrient balance in its leaves while using woody tissues as flexible storage reservoirs. This compartmentalized mechanism buffers the plant from soil phosphorus limitation and microbial competition, resolving the ...
Zhikang Wang   +13 more
wiley   +1 more source

Wafer‐Scale Room‐Temperature Processing of Lead‐Free Perovskites for Optoelectronic Applications

open access: yesAdvanced Science, EarlyView.
We present the first wafer‐scale, room‐temperature synthesis of lead‐free Cs3Sb2X9 (X = Br, I) perovskite films via solvent‐free magnetron sputtering. The resulting high‐performance photodetectors achieve benchmark responsivity, bandwidth, and detectivity, enabling scalable manufacturing for next‐generation optoelectronics.
Rosanna Mastria   +12 more
wiley   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi   +6 more
wiley   +1 more source

Enhancing Binding by Electron Transfer at Heterointerfaces of Biochar‐Modified Hydrogel to Improve Utilization Efficiency of Wastewater Recovered Nutrients

open access: yesAdvanced Science, EarlyView.
Enhancing the utilization efficiency of nutrients recovered from wastewater is achieved through hydrogel modification by biochar. The strategy improves nutrient binding to hydrogels via electron transfer at heterointerfaces, thereby reducing nutrient release rate.
Hao Hu   +7 more
wiley   +1 more source

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