Results 141 to 150 of about 9,883,756 (332)

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Deep learning for knowledge tracing in learning analytics: An overview [PDF]

, 2021
Learning Analytics (LA) is a recent research branch that refers to methods for measuring, collecting, analyzing, and reporting learners’ data, in order to better understand and optimize the processes and the environments.
Santoro, D., Casalino, G., Schicchi, D., Luca Grilli, Pierpaolo Limone, Daniele Schicchi, Limone, P., Gabriella Casalino, Grilli, L., Domenico Santoro   +9 more
core  

Deep Learning Application for Analyzing of Constituents and Their Correlations in the Interpretations of Medical Images

, 2021
The need for time and attention, given by the doctor to the patient, due to the increased volume of medical data to be interpreted and filtered for diagnostic and therapeutic purposes has encouraged the development of the option to support ...
Roxana Grigorovici, Andreea Roxana Luca, Stefan Iancu, Liliana Gheorghe, Alexandru Grigorovici, Tudor Florin Ursuleanu, Cristina Preda, Maria Hlusneac   +7 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Deep learning predicts HER2 status in invasive breast cancer from multimodal ultrasound and MRI

Biomolecules & Biomedicine
The preoperative human epidermal growth factor receptor type 2 (HER2) status of breast cancer is typically determined by pathological examination of a core needle biopsy, which influences the efficacy of neoadjuvant chemotherapy (NAC).
Yuhong Fan, Kaixiang Sun, Yao Xiao, Peng Zhong, Yun Meng, Yang Yang, Zhenwei Du, Jingqin Fang   +7 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Deep learning (DL) Opens New Horizons in Personalized Medicine [PDF]

Biomedical Journal of Scientific & Technical Research, 2018
Although the idea of personalization of patient care dates to the time of Hippocrates, recent advances in diagnostic medical imaging and molecular medicine are gradually transforming health care services, by offering information and diagnostic tools enabling individualized patient management.
openaire   +1 more source

Integrating deep learning techniques for personalized learning pathways in higher education

Heliyon
The rapid improvement of artificial intelligence (AI) in the educational domain has opened new possibilities for enhancing the learning experiences for students.
F. Naseer, Muhammad Nasir Khan, Muhammad Tahir, Abdullah Addas, S.M. Haider Aejaz   +4 more
semanticscholar   +1 more source