Results 261 to 270 of about 20,846,472 (359)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Genome-Wide 6mA Map Unveils Epigenetic Adaptation in Deep-Sea Limpet. [PDF]

Ecol Evol
Chen C, Liu J, Zhuang R, Ni K, Wang M, Li Y, Wang J, Wang S, Han W, Bao L.   +9 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Global Patterns of Mercury Speciation and Biomagnification in Sharks: Ecological Drivers and Food Safety Implications. [PDF]

Environ Sci Technol
Boldrocchi G, Spanu D, Ruiz López A, Garibaldi F, Lanteri L, Maggi A, Bettinetti R, Monticelli D.   +7 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Association between preoperative hypoalbuminemia and surgical site infection in abdominal surgery: a systematic review and meta-analysis. [PDF]

Patient Saf Surg
Omer HFE, Saga MBA, Naser YWS, Mukhtar HMA, Hamed TAM, Ali JOO, Mohamed NA, Mohamed TMA, Dawod HAR, Hassan AHM, Mohamed SOO.   +10 more
europepmc   +1 more source

Improving Groundwater Level Prediction in the Zhuoshui River Basin, Taiwan, through Advanced Deep Learning Methods

Wen‐Ping Tsai, I. Lerche X. Wang, Shao-Wei Ho   +2 more
openalex   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

ConvCGP: A convolutional neural network to predict genetic values of agronomic traits from compressed genome-wide polymorphisms. [PDF]

Plant Genome
Raihan T, Kim CH, Shimono H, Kimura A, Iwata H.   +4 more
europepmc   +1 more source

Recognizing Node Intrusion Tendencies in IoT Environments via Deep Learning and Network-Level Feature Analysis

Ioannis Adamopoulos, Aida Vafae Eslahi, Harshit Mishra, Niki Syrou, Tirus Muya   +4 more
openalex   +2 more sources