Results 181 to 190 of about 19,763 (281)

Deep mutational scanning of the multi-domain phosphatase SHP2 reveals mechanisms of regulation and pathogenicity. [PDF]

Nat Commun
Jiang Z, van Vlimmeren AE, Karandur D, Semmelman A, Shah NH.   +4 more
europepmc   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

Advanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu, Siyuan Chang, Zhaoheng Zhang, Tianqi Kang, Mingde Liu, Yuan Zong, Fei Ni, Yinguang Bao, Ruijie Zhang, Xiaobang Zhang, Jinkun Du, Mingming Xin, Zhaorong Hu, Jie Liu, Zhongfu Ni, Qixin Sun, Yingyin Yao   +16 more
wiley   +1 more source

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors. [PDF]

Nat Commun
Ni X, Richardson RB, Godoy AS, Ferla MP, Kikawa C, Scheen J, Hannon WW, Capkin E, Lahav N, Balcomb BH, Marples PG, Fairhead M, Wang S, Williams EP, Tomlinson CWE, Aschenbrenner JC, Lithgo RM, Winokan M, Giroud C, Dolci I, Fernandes RS, Oliva G, Chandran AV, Xavier MA, Walsh MA, Thompson W, Bloom JD, Kenton NT, Lee AA, von Delft A, Barr H, Kirkegaard K, Koekemoer L, Fearon D, Evans MJ, von Delft F.   +35 more
europepmc   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Rosace-AA: enhancing interpretation of deep mutational scanning data with amino acid substitution and position-specific insights. [PDF]

Bioinform Adv
Rao J, Wang M, Howard MK, Macdonald C, Fraser JS, Coyote-Maestas W, Pimentel H.   +6 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Defining short linear motif binding determinants by phage display-based deep mutational scanning. [PDF]

Protein Sci
Benz C, Maassen L, Simonetti L, Mihalic F, Lindqvist R, Tsitsa I, Konstantinou A, Jemth P, Överby AK, Davey NE, Ivarsson Y.   +10 more
europepmc   +1 more source

Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel [PDF]

, 2017
Ahmad, Aryal, Bao, Bao, Bian, Brelidze, Brinley, Bruening-Wright, Budelli, Cao, Chen, Chen, Chen, Christopher J. Lingle, Contreras, Cox, Cui, del Camino, Ding, Doyle, Díaz, Garg, Geng, Golowasch, Hite, Horrigan, Horrigan, Horrigan, Horrigan, Hu, Huanghe Yang, Jiang, Jiang, Jiang, Jianmin Cui, Koval, Krishnamoorthy, Lee, Lenaeus, Li, Li, Lingle, Liu, Liu, Long, Long, Long, Lu, Ma, Ma, McManus, Meera, Miranda, Niu, Oberhauser, Pantazis, Pathak, Posson, Posson, Prosser, Qian, Roth, Rothberg, Rothberg, Savalli, Schreiber, Schreiber, Schreiber, Shi, Shi, Stefani, Sweet, Tang, Tao, Thompson, Tristani-Firouzi, Wilkens, Wu, Xia, Xia, Yang, Yang, Yang, Yang, Yang, Yang, Yu Zhou, Yuan, Yuan, Zeng, Zhang, Zhang, Zhang, Zhang, Zhou, Zhou, Zhou   +96 more
core   +2 more sources

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source