Results 241 to 250 of about 19,763 (281)

Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex. [PDF]

Immunity
Carr CR, Crawford KHD, Murphy M, Galloway JG, Haddox HK, Matsen FA, Andersen KG, King NP, Bloom JD.   +8 more
europepmc   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. [PDF]

Nat Commun
Lei R, Qing E, Odle A, Yuan M, Gunawardene CD, Tan TJC, So N, Ouyang WO, Wilson IA, Gallagher T, Perlman S, Wu NC, Wong LR.   +12 more
europepmc   +1 more source

Deep mutational scanning reveals transmembrane features governing surface expression of the B cell antigen receptor. [PDF]

Front Immunol
Ramesh S, Go M, Call ME, Call MJ.
europepmc   +1 more source

MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data. [PDF]

Genome Biol
Faure AJ, Lehner B.
europepmc   +1 more source

Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage. [PDF]

Genome Biol
Rao J, Xin R, Macdonald C, Howard MK, Estevam GO, Yee SW, Wang M, Fraser JS, Coyote-Maestas W, Pimentel H.   +9 more
europepmc   +1 more source

Deep mutational scanning of the RNase III-like domain in Trypanosoma brucei RNA editing protein KREPB4. [PDF]

Front Cell Infect Microbiol
McDermott SM, Pham V, Oliver B, Carnes J, Sather DN, Stuart KD.   +5 more
europepmc   +1 more source

Defining short linear motif binding determinants by phage-based multiplexed deep mutational scanning

Benz C, Maasen L, Simonetti L, Mihalic F, Lindqvist R, Tsitsa I, Jemth P, Överby AK, Davey NE, Ivarsson Y.   +9 more
europepmc   +1 more source

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Topological deep learning based deep mutational scanning

Computers in Biology and Medicine, 2023
High-throughput deep mutational scanning (DMS) experiments have significantly impacted protein engineering, drug discovery, immunology, cancer biology, and evolutionary biology by enabling the systematic understanding of protein functions. However, the mutational space associated with proteins is astronomically large, making it overwhelming for current
Jiahui Chen, Daniel R. Woldring, Faqing Huang, Xuefei Huang, Guo-Wei Wei   +4 more
openaire   +2 more sources