Results 51 to 60 of about 42,277 (287)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Postoperative Swallowing Function in Patients with Deep Neck Infection

Biomedicine Hub, 2023
Introduction: Early detection of dysphagia risk, initiating rehabilitation, and resumption of appropriate diet based on swallowing function is important during deep neck infection (DNI) control. This study aimed to evaluate the extent of cervical abscess
Shohei Ashizawa, Takuma Hisaoka, Ryoukichi Ikeda, Rina Kamihata, Jun Suzuki, Ai Hirano-Kawamoto, Jun Ohta, Yukio Katori   +7 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Objective Analysis of Neck Muscle Boundaries for Cervical Dystonia Using Ultrasound Imaging and Deep Learning [PDF]

IEEE Journal of Biomedical and Health Informatics, 2020
To provide objective visualization and pattern analysis of neck muscle boundaries to inform and monitor treatment of cervical dystonia.We recorded transverse cervical ultrasound (US) images and whole-body motion analysis of sixty-one standing participants (35 cervical dystonia, 26 age matched controls).
Ian Loram, Abdul Siddique, María B. Sánchez, Peter J. Harding, Monty Silverdale, Christopher Kobylecki, Ryan Cunningham   +6 more
openaire   +4 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A study of receptors in jaw muscles of the rat and other vertebrates [PDF]

, 1989
The masseteric nerve supplying rat deep masseter muscle was traced from serial paraffin sections. The number of myelinated axons counted in a plastic transverse section close to its entrance into the muscle was 2120. Extrafusal muscle fibre counts of rat
Saed, Hassan Hantosh, Saed, H.H
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Evaluation of neck muscles activation patterns during simple isometric tasks

, 2013
38ième congrès de la Société de Biomécanique francophone, MARSEILLE, FRANCE, 04-/09/2013 - 06/09/2013The ability to move and position one's head in space intrinsically depends on the harmonious operation of about 30 pairs of neck muscles.
LAMOURI, Pierre, Frechede, Bertrand
core   +1 more source

The Effect of Exercise Intervention on Non-Specific Neck Pain and Head and Neck Angles Among Adult Smartphone Users [PDF]

Journal of Health Sciences and Surveillance System
Background: This study aimed to investigate the effect of exercise intervention on non-specific neck pain and head and neck angles among adult smartphone users.Methods: This interventional study was conducted among 84 adults divided into experimental and
Sara Tabanfar, Seyvan Sobhani, Ali Safari Variani, Sakineh Varmazyar   +3 more
doaj   +1 more source