Results 151 to 160 of about 370,356 (314)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
IEEE Transactions on Neural Systems and Rehabilitation EngineeringThe development of advanced prosthetic devices that can be seamlessly used during an individual’s daily life remains a significant challenge in the field of rehabilitation engineering.
Jan Zbinden +2 more
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
The UEDIN English ASR System for the IWSLT 2013 Evaluation
, 2013 This paper describes the University of Edinburgh (UEDIN) English ASR system for the IWSLT 2013 Evaluation. Notable features of the system include deep neural network acoustic models in both tandem and hybrid configuration, cross-domain adaptation with ...
Renals, Steve +5 more
core
Chinese herbal medicines are the treasure of Chinese traditional medicine, which contains active ingredients that have significant therapeutic effects for many diseases.
Lulu Lv +8 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source
Enhancing deep neural network training efficiency and performance through linear prediction
Scientific ReportsDeep neural networks have achieved remarkable success in various fields. However, training an effective deep neural network still poses challenges. This paper aims to propose a method to optimize the training effectiveness of deep neural networks, with ...
Hejie Ying +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source
Spectral Complexity of Deep Neural Networks
SIAM Journal on Mathematics of Data ScienceIt is well-known that randomly initialized, push-forward, fully-connected neural networks weakly converge to isotropic Gaussian processes, in the limit where the width of all layers goes to infinity. In this paper, we propose to use the angular power spectrum of the limiting field to characterize the complexity of the network architecture.
Di Lillo, Simmaco +3 more
openaire +2 more sources