Results 21 to 30 of about 66,347 (239)

Bispectral index versus COMFORT score to determine the level of sedation in paediatric intensive care unit patients: a prospective study [PDF]

, 2004
INTRODUCTION: Most clinicians give sedatives and analgesics according to their professional experience and the patient's estimated need for sedation. However, this approach is prone to error. Inadequate monitoring of sedation and analgesia may contribute
Genähr, Arka, Große, Joachim, Konertz, Wolfgang, Moshirzadeh, Maryam, Nestmann, Grit, Orawa, Helmut, Sander, Michael, Spies, Claudia D, Triltsch, Andreas E   +8 more
core   +2 more sources

Physician reports of terminal sedation without hydration or nutrition for patients nearing death in the Netherlands [PDF]

, 2004
BACKGROUND: Terminal sedation in patients nearing death is an important issue related to end-of-life care. OBJECTIVE: To describe the practice of terminal sedation in the Netherlands. DESIGN: Face-to-face interviews.
Heide, A. (Agnes) van der, Maas, P.J. (Paul) van der, Onwuteaka-Philipsen, B.D. (Bregje), Rietjens, J.A.C. (Judith), Vrakking, A.M. (Astrid), Wal, G. (Gerrit) van der   +5 more
core   +2 more sources

How the mass media report social statistics: A case study concerning research on end-of-life decisions [PDF]

, 2010
This is the post-print version of the final paper published in Social Science & Medicine. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Bauman, Bell, Best, Best, Best, Boyce, Cicourel, Clive Seale, Deacon, Entwistle, Fenton, Fenton, Galtung, Gorer, Harcup, Hausmann, Jackson, Kitzinger, Kitzinger, Kuhse, Langer, Lewis, McInerney, McInerney, McInerney, Mellor, Nelkin, Osborne, Pollock, Rietjens, Schmierbach, Seale, Seale, Seale, Seale, Seale, Seale, Seale, Signorielli, Sparks, Sykes, van der Heide, van der Maas, Wakefield, Williams   +44 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The practice of palliative sedation in the Netherlands after the launch of the national guideline [PDF]

, 2013
Palliative sedation is a medical intervention aimed at relieving intractable suff ering by inducing decreased awareness of symptoms. It is typically considered a palliative option for patients suff ering unbearably in the last days of life. The estimated
Swart, S.J. (Siebe)
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Terminal sedation: pulling the sheet over our eyes [PDF]

, 2008
Journal ArticleTerminal sedation-also called "palliative sedation," "continuous deep sedation," or "primary deep continuous sedation"-has become a new favorite in end-of-life care, a seeming compromise in the debate over physician-assisted dying. Like
Battin, Margaret P.
core   +1 more source

Deep and continuous palliative sedation (terminal sedation): clinical-ethical and philosophical aspects [PDF]

The Lancet Oncology, 2009
Terminal sedation continues to fuel debate. When confronted with a patient for whom terminal sedation is considered a possible treatment option, decision making can be difficult. In this paper we focus on the clinical-ethical issues, with an aim to provide clinicians with ways of framing the issue from an ethical point of view.
Materstvedt, L J, Bosshard, G
openaire   +3 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source