Results 41 to 50 of about 240,619 (265)

Differential Characteristics of Viral siRNAs between Leaves and Roots of Wheat Plants Naturally Infected with Wheat Yellow Mosaic Virus, a Soil-Borne Virus

Frontiers in Microbiology, 2017
RNA silencing is an important innate antiviral defense in plants. Soil-borne plant viruses naturally infect roots via soil-inhabiting vectors, but it is unclear how antiviral RNA silencing responds to virus infection in this particular tissue.
Linying Li, Linying Li, Linying Li, Ida Bagus Andika, Yu Xu, Yu Xu, Yan Zhang, Yan Zhang, Xiangqi Xin, Lifeng Hu, Lifeng Hu, Zongtao Sun, Zongtao Sun, Gaojie Hong, Gaojie Hong, Yang Chen, Yang Chen, Fei Yan, Fei Yan, Jian Yang, Jian Yang, Junmin Li, Junmin Li, Junmin Li, Jianping Chen, Jianping Chen, Jianping Chen   +26 more
doaj   +1 more source

Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST

Frontiers in Oncology, 2020
Background: Gastrointestinal stromal tumors (GIST) are known to carry oncogenic KIT or PDGFRA mutations, or less commonly SDH or NF1 gene inactivation, with very rare cases harboring mutant BRAF or RAS alleles.
Annalisa Astolfi, Valentina Indio, Margherita Nannini, Margherita Nannini, Maristella Saponara, Angela Schipani, Antonio De Leo, Annalisa Altimari, Bruno Vincenzi, Danila Comandini, Giovanni Grignani, Paola Secchiero, Milena Urbini, Maria Abbondanza Pantaleo, Maria Abbondanza Pantaleo   +14 more
doaj   +1 more source

Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires

Frontiers in Immunology, 2021
Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mAb ...
Brian M. Petersen, Sophia A. Ulmer, Emily R. Rhodes, Matias F. Gutierrez-Gonzalez, Brandon J. Dekosky, Brandon J. Dekosky, Kayla G. Sprenger, Timothy A. Whitehead   +7 more
doaj   +1 more source

Spatial transcriptomics in embryonic mouse diaphragm muscle reveals regional gradients and subdomains of developmental gene expression

iScience
Summary: The murine embryonic diaphragm is a primary model for studying myogenesis and neuro-muscular synaptogenesis, both representing processes regulated by spatially organized genetic programs of myonuclei located in distinct myodomains.
Mehmet Mahsum Kaplan, Maximilian Zeidler, Annabella Knapp, Martina Hölzl, Michaela Kress, Helga Fritsch, Anne Krogsdam, Bernhard E. Flucher   +7 more
doaj   +1 more source

Metagenomic Analysis of RNA Fraction Reveals the Diversity of Swine Oral Virome on South African Backyard Swine Farms in the uMgungundlovu District of KwaZulu-Natal Province

Pathogens, 2022
Numerous RNA viruses have been reported in backyard swine populations in various countries. In the absence of active disease surveillance, a persistent knowledge gap exists on the diversity of RNA viruses in South African backyard swine populations. This
Ravendra P. Chauhan, James E. San, Michelle L. Gordon   +2 more
doaj   +1 more source

Stressful Events Reported by Childhood Cancer Survivors and Community Controls From the St. Jude Lifetime (SJLIFE) Cohort: A Mixed Method Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware, Colter K. Clayton, Fang Wang, Sedigheh Mirzaei, Kyla Shelton, Tara M. Brinkman, Victoria Willard, Katianne M. Howard Sharp, Kevin Krull, Lindsay F. Schwartz, Melissa M. Hudson, Gregory T. Armstrong, Kirsten K. Ness, Rachel T. Webster   +13 more
wiley   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Deep sequencing of the mouse lung transcriptome reveals distinct long non-coding RNAs expression associated with the high virulence of H5N1 avian influenza virus in mice

Virulence, 2018
Long non-coding RNAs (lncRNAs) play multiple key regulatory roles in various biological processes. However, their function in influenza A virus (IAV) pathogenicity remains largely unexplored.
Jiao Hu, Zenglei Hu, Xiaoquan Wang, Min Gu, Zhao Gao, Yanyan Liang, Chunxi Ma, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu   +12 more
doaj   +1 more source

Adaptation in protein fitness landscapes is facilitated by indirect paths

eLife, 2016
The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double ...
Nicholas C Wu, Lei Dai, C Anders Olson, James O Lloyd-Smith, Ren Sun   +4 more
doaj   +1 more source

Therapy-Acquired Clonal Mutations in Thiopurine Drug-Response Genes Drive Majority of Early Relapses in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Diagnostics, 2023
Methods: Forty pediatric (0–12 years) B-ALL DNA samples (20 paired Diagnosis-Relapse) and an additional six B-ALL DNA samples (without relapse at 3 years post treatment), as the non-relapse arm, were retrieved from the biobank for advanced genomic ...
Rozy Thakur, Prateek Bhatia, Minu Singh, Sreejesh Sreedharanunni, Pankaj Sharma, Aditya Singh, Amita Trehan   +6 more
doaj   +1 more source